Abstract
Background: Urinary tract–related bloodstream infection (BSI) is associated with substantial morbidity, mortality, and financial costs. We examined the role of red blood cell (RBC) transfusions on developing this condition among US Veterans. Methods: We conducted a matched case-control study among adult inpatients admitted to 4 Veterans Affairs hospitals. Cases were patients with a positive urine culture result obtained 48 hours or longer after admission and a blood culture obtained within 14 days of the urine culture, which grew the same organism. Controls included patients with a positive urine culture result who were at risk for but did not develop BSI (control group 1) and patients without a positive urine culture result who were present in the facility at the time of case diagnosis (control group 2). Results: Compared with the findings in control group 1, receipt of RBCs was not significantly associated with urinary tract–related BSI (odds ratio, 1.03; 95% confidence interval, 1.00-1.07; P = .07). However, we found increased odds of urinary tract–related BSI compared with the results in patients without infection (control group 2) (odds ratio, 1.11; 95% confidence interval, 1.06-1.17; P < .001). Conclusions: Given the heightened risk of urinary tract–related BSI associated with receiving a greater number of RBC transfusions, adhering to recommendations to transfuse the minimum amount of blood products necessary may minimize the risk of this infection among Veterans.
| Original language | English (US) |
|---|---|
| Journal | American Journal of Infection Control |
| DOIs | |
| State | Accepted/In press - Jan 1 2018 |
| Externally published | Yes |
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Keywords
- Health care–associated infectionBlood transfusion
ASJC Scopus subject areas
- Epidemiology
- Health Policy
- Public Health, Environmental and Occupational Health
- Infectious Diseases
Cite this
Role of transfusions in the development of hospital-acquired urinary tract–related bloodstream infection among United States Veterans. / Greene, M. Todd; Saint, Sanjay; Ratz, David; Kuhn, Latoya; Davis, Jennifer I.M.; Patel, Payal K.; Rogers, Mary A.M.
In: American Journal of Infection Control, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Role of transfusions in the development of hospital-acquired urinary tract–related bloodstream infection among United States Veterans
AU - Greene, M. Todd
AU - Saint, Sanjay
AU - Ratz, David
AU - Kuhn, Latoya
AU - Davis, Jennifer I.M.
AU - Patel, Payal K.
AU - Rogers, Mary A.M.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Background: Urinary tract–related bloodstream infection (BSI) is associated with substantial morbidity, mortality, and financial costs. We examined the role of red blood cell (RBC) transfusions on developing this condition among US Veterans. Methods: We conducted a matched case-control study among adult inpatients admitted to 4 Veterans Affairs hospitals. Cases were patients with a positive urine culture result obtained 48 hours or longer after admission and a blood culture obtained within 14 days of the urine culture, which grew the same organism. Controls included patients with a positive urine culture result who were at risk for but did not develop BSI (control group 1) and patients without a positive urine culture result who were present in the facility at the time of case diagnosis (control group 2). Results: Compared with the findings in control group 1, receipt of RBCs was not significantly associated with urinary tract–related BSI (odds ratio, 1.03; 95% confidence interval, 1.00-1.07; P = .07). However, we found increased odds of urinary tract–related BSI compared with the results in patients without infection (control group 2) (odds ratio, 1.11; 95% confidence interval, 1.06-1.17; P < .001). Conclusions: Given the heightened risk of urinary tract–related BSI associated with receiving a greater number of RBC transfusions, adhering to recommendations to transfuse the minimum amount of blood products necessary may minimize the risk of this infection among Veterans.
AB - Background: Urinary tract–related bloodstream infection (BSI) is associated with substantial morbidity, mortality, and financial costs. We examined the role of red blood cell (RBC) transfusions on developing this condition among US Veterans. Methods: We conducted a matched case-control study among adult inpatients admitted to 4 Veterans Affairs hospitals. Cases were patients with a positive urine culture result obtained 48 hours or longer after admission and a blood culture obtained within 14 days of the urine culture, which grew the same organism. Controls included patients with a positive urine culture result who were at risk for but did not develop BSI (control group 1) and patients without a positive urine culture result who were present in the facility at the time of case diagnosis (control group 2). Results: Compared with the findings in control group 1, receipt of RBCs was not significantly associated with urinary tract–related BSI (odds ratio, 1.03; 95% confidence interval, 1.00-1.07; P = .07). However, we found increased odds of urinary tract–related BSI compared with the results in patients without infection (control group 2) (odds ratio, 1.11; 95% confidence interval, 1.06-1.17; P < .001). Conclusions: Given the heightened risk of urinary tract–related BSI associated with receiving a greater number of RBC transfusions, adhering to recommendations to transfuse the minimum amount of blood products necessary may minimize the risk of this infection among Veterans.
KW - Health care–associated infectionBlood transfusion
UR - http://www.scopus.com/inward/record.url?scp=85056752531&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85056752531&partnerID=8YFLogxK
U2 - 10.1016/j.ajic.2018.09.013
DO - 10.1016/j.ajic.2018.09.013
M3 - Article
C2 - 30470527
AN - SCOPUS:85056752531
JO - American Journal of Infection Control
JF - American Journal of Infection Control
SN - 0196-6553
ER -