Role of the ribosome in protein folding

Debasis Das, Anindita Das, Dibyendu Samanta, Jaydip Ghosh, Santanu Dasgupta, Arpita Bhattacharya, Arunima Basu, Supama Sanyal, Chanchal Das Gupta

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

In all organisms, the ribosome synthesizes and folds full length polypeptide chains into active three-dimensional conformations. The nascent protein goes through two major interactions, first with the ribosome which synthesizes the polypeptide chain and holds it for a considerable length of time, and then with the chaperones. Some of the chaperones are found in solution as well as associated to the ribosome. A number of in vitro and in vivo experiments revealed that the nascent protein folds through specific interactions of some amino acids with the nucleotides in the peptidyl transferase center (PTC) in the large ribosomal subunit. The mechanism of this folding differs from self-folding. In this article, we highlight the folding of nascent proteins on the ribosome and the influence of chaperones etc. on protein folding.

Original languageEnglish (US)
Pages (from-to)999-1009
Number of pages11
JournalBiotechnology Journal
Volume3
Issue number8
DOIs
StatePublished - Aug 2008
Externally publishedYes

Fingerprint

Protein Folding
Ribosomes
Large Ribosome Subunits
Peptidyl Transferases
Peptides
Proteins
Nucleotides
Amino Acids

Keywords

  • 50S subunit
  • Chaperones
  • Domain V rRNA
  • Protein folding
  • Ribosome

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Molecular Medicine

Cite this

Das, D., Das, A., Samanta, D., Ghosh, J., Dasgupta, S., Bhattacharya, A., ... Das Gupta, C. (2008). Role of the ribosome in protein folding. Biotechnology Journal, 3(8), 999-1009. https://doi.org/10.1002/biot.200800098

Role of the ribosome in protein folding. / Das, Debasis; Das, Anindita; Samanta, Dibyendu; Ghosh, Jaydip; Dasgupta, Santanu; Bhattacharya, Arpita; Basu, Arunima; Sanyal, Supama; Das Gupta, Chanchal.

In: Biotechnology Journal, Vol. 3, No. 8, 08.2008, p. 999-1009.

Research output: Contribution to journalArticle

Das, D, Das, A, Samanta, D, Ghosh, J, Dasgupta, S, Bhattacharya, A, Basu, A, Sanyal, S & Das Gupta, C 2008, 'Role of the ribosome in protein folding', Biotechnology Journal, vol. 3, no. 8, pp. 999-1009. https://doi.org/10.1002/biot.200800098
Das D, Das A, Samanta D, Ghosh J, Dasgupta S, Bhattacharya A et al. Role of the ribosome in protein folding. Biotechnology Journal. 2008 Aug;3(8):999-1009. https://doi.org/10.1002/biot.200800098
Das, Debasis ; Das, Anindita ; Samanta, Dibyendu ; Ghosh, Jaydip ; Dasgupta, Santanu ; Bhattacharya, Arpita ; Basu, Arunima ; Sanyal, Supama ; Das Gupta, Chanchal. / Role of the ribosome in protein folding. In: Biotechnology Journal. 2008 ; Vol. 3, No. 8. pp. 999-1009.
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