Role of manganese in neurodegenerative diseases

Aaron B. Bowman, Gunnar F. Kwakye, Elena Herrero Hernández, Michael Aschner

Research output: Contribution to journalArticle

191 Citations (Scopus)

Abstract

Manganese (Mn) is an essential ubiquitous trace element that is required for normal growth, development and cellular homeostasis. Exposure to high Mn levels causes a clinical disease characterized by extrapyramidal symptom resembling idiopathic Parkinson's disease (IPD). The present review focuses on the role of various transporters in maintaining brain Mn homeostasis along with recent methodological advances in real-time measurements of intracellular Mn levels. We also provide an overview on the role for Mn in IPD, discussing the similarities (and differences) between manganism and IPD, and the relationship between α-synuclein and Mn-related protein aggregation, as well as mitochondrial dysfunction, Mn and PD. Additional sections of the review discuss the link between Mn and Huntington's disease (HD), with emphasis on huntingtin function and the potential role for altered Mn homeostasis and toxicity in HD. We conclude with a brief survey on the potential role of Mn in the etiologies of Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS) and prion disease. Where possible, we discuss the mechanistic commonalities inherent to Mn-induced neurotoxicity and neurodegenerative disorders.

Original languageEnglish (US)
Pages (from-to)191-203
Number of pages13
JournalJournal of Trace Elements in Medicine and Biology
Volume25
Issue number4
DOIs
StatePublished - Dec 2011
Externally publishedYes

Fingerprint

Neurodegenerative diseases
Manganese
Neurodegenerative Diseases
Parkinson Disease
Homeostasis
Huntington Disease
Synucleins
Prion Diseases
Prions
Amyotrophic Lateral Sclerosis
Trace Elements
Time measurement
Growth and Development
Toxicity
Brain
Alzheimer Disease
Agglomeration

Keywords

  • Essentiality
  • Manganese
  • Neurodegenerative diseases
  • Transport

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry
  • Molecular Medicine

Cite this

Role of manganese in neurodegenerative diseases. / Bowman, Aaron B.; Kwakye, Gunnar F.; Herrero Hernández, Elena; Aschner, Michael.

In: Journal of Trace Elements in Medicine and Biology, Vol. 25, No. 4, 12.2011, p. 191-203.

Research output: Contribution to journalArticle

Bowman, Aaron B. ; Kwakye, Gunnar F. ; Herrero Hernández, Elena ; Aschner, Michael. / Role of manganese in neurodegenerative diseases. In: Journal of Trace Elements in Medicine and Biology. 2011 ; Vol. 25, No. 4. pp. 191-203.
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