Role of endothelin receptors in the control of central nervous system parasitism in Trypanosoma cruzi infection in rats

Milene A. Rachid, Antônio L. Teixeira, Lucíola S. Barcelos, Conceição R.S. Machado, Egler Chiari, Herbert B. Tanowitz, Elizabeth R.S. Camargos, Mauro M. Teixeira

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Endothelin has been implicated in the pathogenesis of experimental and human Chagas disease. In the present study, we investigated whether the treatment with bosentan, an antagonist of both ETA/ETB endothelin receptors, modified parasite load and inflammation in the central nervous system (CNS) of Trypanosoma cruzi-infected rats. The cerebellum was the most affected region in the CNS with marked parasitism and inflammation. Treatment with bosentan enhanced parasitemia and CNS parasitism, but control of infection was eventually attained. There was also an increase in the levels of the cytokines TNF-α, IL-10, IFN-γ, CCL2/MCP-1, CCL3/MIP-1α and CCL5/RANTES in the brain of infected animals at days 9, 13 and 18 after infection. Overall, bosentan has some effects on the expression of certain cytokines and this may be related to the initial enhanced parasite load. Altogether, our data suggest that endothelin action via ETA and ETB receptors may play a role in the initial resistance of the CNS to T. cruzi infection in rats.

Original languageEnglish (US)
Pages (from-to)64-68
Number of pages5
JournalJournal of Neuroimmunology
Volume220
Issue number1-2
DOIs
StatePublished - Mar 30 2010

Keywords

  • Central nervous system
  • Chagas disease
  • Chemokines
  • Endothelin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Role of endothelin receptors in the control of central nervous system parasitism in Trypanosoma cruzi infection in rats'. Together they form a unique fingerprint.

  • Cite this

    Rachid, M. A., Teixeira, A. L., Barcelos, L. S., Machado, C. R. S., Chiari, E., Tanowitz, H. B., Camargos, E. R. S., & Teixeira, M. M. (2010). Role of endothelin receptors in the control of central nervous system parasitism in Trypanosoma cruzi infection in rats. Journal of Neuroimmunology, 220(1-2), 64-68. https://doi.org/10.1016/j.jneuroim.2010.01.008