Role of endogenous substance P in stress-induced activation of mesocortical dopamine neurones

M. J. Bannon, P. J. Elliott, Jonathan E. Alpert, M. Goedert, S. D. Iversen, L. L. Iversen

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

The dopamine (DA) innervation to the forebrain arises from subpopulations of midbrain DA neurones broadly classified as nigrostriatal, mesolimbic and mesocortical1. Significant differences in the autoregulatory mechanisms and neuronal inputs of these DA pathways may account for their differences in physiological and pharmacological responsiveness2. For example, foot-shock stress can activate rat mesocortical DA cells but does not alter nigrostriatal DA turnover3-5, while also decreasing substance P (SP) concentrations in the midbrain interpeduncular nucleus and in the adjacent ventral tegmental area (VTA), but not in the substantia nigra (SN)6. This suggested that the activation of the SP input to the VTA6 may mediate activation of certain DA systems by footshock stress (Fig. 1); behavioural studies also had suggested an excitatory effect of SP on DA cells in the VTA7. SP antagonists now available are neurotoxic8 and of questionable efficacy9, we therefore used monoclonal antibody against SP. Antibody microinjected into the VTA prevented normal footshock-induced activation of mesocortical DA neurones, suggesting mediation by SP input to the VTA. The in vivo application of antibodies may prove valuable in studies of neuropeptides in the central nervous system (CNS).

Original languageEnglish (US)
Pages (from-to)791-792
Number of pages2
JournalNature
Volume306
Issue number5945
DOIs
StatePublished - 1983
Externally publishedYes

Fingerprint

Dopaminergic Neurons
Substance P
Dopamine
Ventral Tegmental Area
Mesencephalon
Antibodies
Substantia Nigra
Prosencephalon
Neuropeptides
Foot
Shock
Central Nervous System
Monoclonal Antibodies
Pharmacology

ASJC Scopus subject areas

  • Medicine(all)
  • General

Cite this

Bannon, M. J., Elliott, P. J., Alpert, J. E., Goedert, M., Iversen, S. D., & Iversen, L. L. (1983). Role of endogenous substance P in stress-induced activation of mesocortical dopamine neurones. Nature, 306(5945), 791-792. https://doi.org/10.1038/306791a0

Role of endogenous substance P in stress-induced activation of mesocortical dopamine neurones. / Bannon, M. J.; Elliott, P. J.; Alpert, Jonathan E.; Goedert, M.; Iversen, S. D.; Iversen, L. L.

In: Nature, Vol. 306, No. 5945, 1983, p. 791-792.

Research output: Contribution to journalArticle

Bannon, MJ, Elliott, PJ, Alpert, JE, Goedert, M, Iversen, SD & Iversen, LL 1983, 'Role of endogenous substance P in stress-induced activation of mesocortical dopamine neurones', Nature, vol. 306, no. 5945, pp. 791-792. https://doi.org/10.1038/306791a0
Bannon, M. J. ; Elliott, P. J. ; Alpert, Jonathan E. ; Goedert, M. ; Iversen, S. D. ; Iversen, L. L. / Role of endogenous substance P in stress-induced activation of mesocortical dopamine neurones. In: Nature. 1983 ; Vol. 306, No. 5945. pp. 791-792.
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