Role of endogenous CCK in the inhibition of gastric emptying by peptone and Intralipid in rats

Wesley O. White, Gary J. Schwartz, Timothy H. Moran

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

To assess the role of endogenous cholecystokinin in the control of gastric emptying of peptone solutions and Intralipid suspensions, we examined the ability of a dose range of the CCK-A antagonist, devazepide to accelerate the gastric emptying of various caloric concentrations of peptone and Intralipid in rats. In the absence of devazepide, both peptone and Intralipid emptying slowed with increasing concentration. Devazepide's effect on peptone gastric emptying diminished with increasing peptone concentration. The threshold dose for accelerating the emptying of 0.2 kcal/ml peptone was lower than the threshold dose for affecting 0.5 kcal/ml peptone and devazepide had no effect on the gastric emptying of 1.0 kcal/ml peptone. In contrast, devazepide affected Intralipid gastric emptying at all three Intralipid concentrations and the threshold dose decreased with increasing Intralipid concentration. However, the magnitude of the effect of devazepide on peptone or Intralipid gastric emptying was partial and did not increase as a function of concentration. These data demonstrate a role for endogenous CCK in the emptying of peptone and Intralipid but suggest that endogenous CCK does not account for the increased slowing of gastric emptying evident with increased caloric concentration Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)47-53
Number of pages7
JournalRegulatory Peptides
Volume88
Issue number1-3
DOIs
StatePublished - Mar 17 2000
Externally publishedYes

Fingerprint

Peptones
Gastric Emptying
Devazepide
Rats
phospholipid emulsion soybean oil
Cholecystokinin
Suspensions

Keywords

  • Control of gastric emptying
  • Endogenous cholecystokinin
  • Intralipid suspensions

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Neuroscience(all)

Cite this

Role of endogenous CCK in the inhibition of gastric emptying by peptone and Intralipid in rats. / White, Wesley O.; Schwartz, Gary J.; Moran, Timothy H.

In: Regulatory Peptides, Vol. 88, No. 1-3, 17.03.2000, p. 47-53.

Research output: Contribution to journalArticle

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