Role of cavitation in bulk ultrasound ablation: A histologic study

Chandra Priya Karunakaran, Mark T. Burgess, Christy K. Holland, T. Douglas Mast

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

The role of cavitation in bulk ultrasound ablation has been evaluated in a series of in vitro experiments. Fresh bovine liver tissue was ablated with a 3.1 MHz ultrasound image-ablate probe at 31 W/cm 2 for 20 minutes under normal and elevated ambient pressures. A 1 MHz passive cavitation detector recorded acoustic emission signals which were quantified by computation of average subharmonic, broadband, and low-frequency emission levels. After ablation, tissue was sliced and stained with 2% TTC to evaluate thermal damage. Emission levels were quantified and correlated with tissue ablation histology. The results indicate that bubble activity significantly affects heat deposition in ultrasound bulk ablation, in a manner different from high-intensity focused ultrasound (HIFU) ablation.

Original languageEnglish (US)
Title of host publication8th International Symposium on Therapeutic Ultrasound
Pages43-47
Number of pages5
DOIs
Publication statusPublished - Jul 21 2009
Externally publishedYes
Event8th International Symposium on Therapeutic Ultrasound - Minneapolis, MN, United States
Duration: Sep 10 2008Sep 13 2008

Publication series

NameAIP Conference Proceedings
Volume1113
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference8th International Symposium on Therapeutic Ultrasound
CountryUnited States
CityMinneapolis, MN
Period9/10/089/13/08

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Keywords

  • Bulk ultrasound ablation
  • Passive cavitation detection
  • TTC staining

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Karunakaran, C. P., Burgess, M. T., Holland, C. K., & Mast, T. D. (2009). Role of cavitation in bulk ultrasound ablation: A histologic study. In 8th International Symposium on Therapeutic Ultrasound (pp. 43-47). (AIP Conference Proceedings; Vol. 1113). https://doi.org/10.1063/1.3131467