Role of candida in pathogenesis of antibiotic-associated diarrhoea in elderly inpatients

P. L. Danna, Carl Urban, J. J. Rahal, Eran Bellin, J. J. Rahal, Carl Urban

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Abstract

The part that candida plays in antibiotic-associated diarrhoea was investigated in 24 elderly inpatients (mean age 74 years) who tested negative for Clostridium difficile toxin and other intestinal pathogens. 7 had intestinal overgrowth of Candida species (≥105 cfu/ml). None of the 24 matched, antibiotic-treated controls without diarrhoea had candida overgrowth. All 5 patients with diarrhoea and candida overgrowth treated with oral nystatin responded with resolution of diarrhoea and lowering of faecal counts to < 104 cfu/ml within 7 days of start of antifungal therapy despite continuation of antibacterial therapy. In the other 2 patients with candida overgrowth, the diarrhoea subsided spontaneously and faecal candida counts returned to normal (<104 cfu/ml) after antibacterial agents were withdrawn. In patients without candida overgrowth, diarrhoea persisted until antibiotics were withdrawn, at a mean of 16 days after study entry.

Original languageEnglish (US)
Pages (from-to)511-514
Number of pages4
JournalThe Lancet
Volume337
Issue number8740
DOIs
Publication statusPublished - Mar 2 1991

ASJC Scopus subject areas

  • Medicine(all)

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