Role of astrocytes in brain function and disease.

Marta Sidoryk-Wegrzynowicz, Michal Wegrzynowicz, Eunsook Lee, Aaron B. Bowman, Michael Aschner

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Astrocytes assume multiple roles in maintaining an optimally suited milieu for neuronal function. Select astrocytic functions include the maintenance of redox potential, the production of trophic factors, the regulation of neurotransmitter and ion concentrations, and the removal of toxins and debris from the cerebrospinal fluid (CSF). Impairments in these and other functions, as well as physiological reactions of astrocytes to injury, can trigger or exacerbate neuronal dysfunction. This review addresses select metabolic interactions between neurons and astrocytes and emphasizes the role of astrocytes in mediating and amplifying the progression of several neurodegenerative disorders, such as Parkinson's disease (PD), hepatic encephalopathy (HE), hyperammonemia (HA), Alzheimer's disease (AD), and ischemia.

Original languageEnglish (US)
Pages (from-to)115-123
Number of pages9
JournalToxicologic Pathology
Volume39
Issue number1
DOIs
StatePublished - 2011
Externally publishedYes

Fingerprint

Brain Diseases
Astrocytes
Brain
Cerebrospinal fluid
Hyperammonemia
Hepatic Encephalopathy
Debris
Neurodegenerative Diseases
Neurons
Oxidation-Reduction
Neurotransmitter Agents
Parkinson Disease
Cerebrospinal Fluid
Alzheimer Disease
Ischemia
Maintenance
Ions
Wounds and Injuries

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Cell Biology
  • Molecular Biology

Cite this

Sidoryk-Wegrzynowicz, M., Wegrzynowicz, M., Lee, E., Bowman, A. B., & Aschner, M. (2011). Role of astrocytes in brain function and disease. Toxicologic Pathology, 39(1), 115-123. https://doi.org/10.1177/0192623310385254

Role of astrocytes in brain function and disease. / Sidoryk-Wegrzynowicz, Marta; Wegrzynowicz, Michal; Lee, Eunsook; Bowman, Aaron B.; Aschner, Michael.

In: Toxicologic Pathology, Vol. 39, No. 1, 2011, p. 115-123.

Research output: Contribution to journalArticle

Sidoryk-Wegrzynowicz, M, Wegrzynowicz, M, Lee, E, Bowman, AB & Aschner, M 2011, 'Role of astrocytes in brain function and disease.', Toxicologic Pathology, vol. 39, no. 1, pp. 115-123. https://doi.org/10.1177/0192623310385254
Sidoryk-Wegrzynowicz M, Wegrzynowicz M, Lee E, Bowman AB, Aschner M. Role of astrocytes in brain function and disease. Toxicologic Pathology. 2011;39(1):115-123. https://doi.org/10.1177/0192623310385254
Sidoryk-Wegrzynowicz, Marta ; Wegrzynowicz, Michal ; Lee, Eunsook ; Bowman, Aaron B. ; Aschner, Michael. / Role of astrocytes in brain function and disease. In: Toxicologic Pathology. 2011 ; Vol. 39, No. 1. pp. 115-123.
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