Role of Antithrombin III and Tissue Factor Pathway in the Pathogenesis of Sepsis

Sarah Sungurlu, Jessica Kuppy, Robert A. Balk

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

The pathobiology of the septic process includes a complex interrelationship between inflammation and the coagulations system. Antithrombin (AT) and tissue factor are important components of the coagulation system and have potential roles in the production and amplification of sepsis. Sepsis is associated with a decrease in AT levels, and low levels are also associated with the development of multiple organ failure and death. Treatment strategies incorporating AT replacement therapy in sepsis and septic shock have not resulted in an improvement in survival or reversal of disseminated intravascular coagulation.

Original languageEnglish (US)
Pages (from-to)255-265
Number of pages11
JournalCritical Care Clinics
Volume36
Issue number2
DOIs
StatePublished - Apr 2020
Externally publishedYes

Keywords

  • Antithrombin
  • Coagulopathy
  • Multiple organ failure
  • Sepsis
  • Tissue factor

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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