Abstract
The pathobiology of the septic process includes a complex interrelationship between inflammation and the coagulations system. Antithrombin (AT) and tissue factor are important components of the coagulation system and have potential roles in the production and amplification of sepsis. Sepsis is associated with a decrease in AT levels, and low levels are also associated with the development of multiple organ failure and death. Treatment strategies incorporating AT replacement therapy in sepsis and septic shock have not resulted in an improvement in survival or reversal of disseminated intravascular coagulation.
Original language | English (US) |
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Pages (from-to) | 255-265 |
Number of pages | 11 |
Journal | Critical Care Clinics |
Volume | 36 |
Issue number | 2 |
DOIs | |
State | Published - Apr 2020 |
Externally published | Yes |
Keywords
- Antithrombin
- Coagulopathy
- Multiple organ failure
- Sepsis
- Tissue factor
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine