TY - JOUR
T1 - Role of ABO blood type in delayed cerebral ischemia onset and clinical outcomes after aneurysmal subarachnoid hemorrhage in an ethnic minority urban population
AU - Unda, Santiago René
AU - Vats, Tarini
AU - De La Garza Ramos, Rafael
AU - Cezaryirli, Phillip
AU - Altschul, David J.
N1 - Publisher Copyright:
© 2020 Scientific Scholar. All rights reserved.
PY - 2020/5/16
Y1 - 2020/5/16
N2 - Background: In recent years, the role of ABO blood type moved into focus through the discovery of different hemostaseologic properties with importance in many diseases including subarachnoid hemorrhage (SAH). However, the role of ABO blood type in delayed cerebral ischemia (DCI) onset, clinical progress, and outcome after SAH is to date largely unexplored. Our aim was to explore the role of ABO blood group in DCI and clinical outcomes after aneurysmal SAH (aSAH). Methods: A retrospective analysis was made with data collected from patients who presented aSAH at our single-academic center from 2015 to 2018. We included demographic, clinical, and imaging variables in the univariate analysis and in the subsequent multivariate analysis. Results: A total of 204 patients were included in this study. About 17.9% of "O" type patients developed a DCI while DCI was reported in only 8.2% of non-O type patients (P = 0.04). "O" type was an independent risk after in the logistic regression after adjusting for significant factors in the univariate analysis (OR=2.530, 95% CI: 1.040-6.151, P = 0.41). Compared to "non-O" type patients, "O" type patients had a trend to have poorer outcomes at discharge (25.5% vs. 21.3%, P = 0.489) and at 12-18 months (21.1% vs. 19.5%, P = 0.795). However, there were no significant differences. Conclusion: Our study evidenced that patients with "O" blood type have higher risk of DCI onset after aSAH. Although these findings need to be confirmed, they may aid to improve DCI prevention and outcome predictions.
AB - Background: In recent years, the role of ABO blood type moved into focus through the discovery of different hemostaseologic properties with importance in many diseases including subarachnoid hemorrhage (SAH). However, the role of ABO blood type in delayed cerebral ischemia (DCI) onset, clinical progress, and outcome after SAH is to date largely unexplored. Our aim was to explore the role of ABO blood group in DCI and clinical outcomes after aneurysmal SAH (aSAH). Methods: A retrospective analysis was made with data collected from patients who presented aSAH at our single-academic center from 2015 to 2018. We included demographic, clinical, and imaging variables in the univariate analysis and in the subsequent multivariate analysis. Results: A total of 204 patients were included in this study. About 17.9% of "O" type patients developed a DCI while DCI was reported in only 8.2% of non-O type patients (P = 0.04). "O" type was an independent risk after in the logistic regression after adjusting for significant factors in the univariate analysis (OR=2.530, 95% CI: 1.040-6.151, P = 0.41). Compared to "non-O" type patients, "O" type patients had a trend to have poorer outcomes at discharge (25.5% vs. 21.3%, P = 0.489) and at 12-18 months (21.1% vs. 19.5%, P = 0.795). However, there were no significant differences. Conclusion: Our study evidenced that patients with "O" blood type have higher risk of DCI onset after aSAH. Although these findings need to be confirmed, they may aid to improve DCI prevention and outcome predictions.
KW - ABO blood type
KW - Aneurysm
KW - Delayed cerebral ischemia
KW - Subarachnoid hemorrhage
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U2 - 10.25259/SNI_10_2020
DO - 10.25259/SNI_10_2020
M3 - Article
AN - SCOPUS:85086858275
SN - 2152-7806
VL - 11
JO - Surgical Neurology International
JF - Surgical Neurology International
IS - 108
M1 - 108
ER -