Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

Leila Alland, Rebecca Muhle, Harry Hou, Jason Potes, Lynda Chin, Nicole Schreiber-Agus, Ronald A. DePinho

Research output: Contribution to journalArticle

712 Scopus citations

Abstract

Normal mammalian growth and development are highly dependent on the regulation of the expression and activity of the Myc family of transcription factors. Mxl1-mediated inhibition of Myc activities requires interaction with mammalian Sin3A or Sin3B proteins, which have been purported to act as scaffolds for additional co-repressor factors. The identification of two such Sin3-associated factors, the nuclear receptor co-repressor (N-CoR) and histone deacetylase (HD1), provides a basis for Mxl1/Sin3-induced transcriptional repression and tumour suppression.

Original languageEnglish (US)
Pages (from-to)49-55
Number of pages7
JournalNature
Volume387
Issue number6628
DOIs
StatePublished - May 1 1997

ASJC Scopus subject areas

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    Alland, L., Muhle, R., Hou, H., Potes, J., Chin, L., Schreiber-Agus, N., & DePinho, R. A. (1997). Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression. Nature, 387(6628), 49-55. https://doi.org/10.1038/387049a0