Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

Leila Alland, Rebecca Muhle, Harry Hou, Jason Potes, Lynda Chin, Nicole Schreiber-Agus, Ronald A. DePinho

Research output: Contribution to journalArticlepeer-review

716 Scopus citations

Abstract

Normal mammalian growth and development are highly dependent on the regulation of the expression and activity of the Myc family of transcription factors. Mxl1-mediated inhibition of Myc activities requires interaction with mammalian Sin3A or Sin3B proteins, which have been purported to act as scaffolds for additional co-repressor factors. The identification of two such Sin3-associated factors, the nuclear receptor co-repressor (N-CoR) and histone deacetylase (HD1), provides a basis for Mxl1/Sin3-induced transcriptional repression and tumour suppression.

Original languageEnglish (US)
Pages (from-to)49-55
Number of pages7
JournalNature
Volume387
Issue number6628
DOIs
StatePublished - May 1 1997
Externally publishedYes

ASJC Scopus subject areas

  • General

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