RNP transport in cell biology: the long and winding road

Research output: Contribution to journalReview article

22 Citations (Scopus)

Abstract

Regulation of gene expression is key determinant to cell structure and function. RNA localization, where specific mRNAs are transported to subcellular regions and then translated, is highly conserved in eukaryotes ranging from yeast to extremely specialized and polarized cells such as neurons. Messenger RNA and associated proteins (mRNP) move from the site of transcription in the nucleus to their final destination in the cytoplasm both passively through diffusion and actively via directed transport. Dysfunction of RNA localization, transport and translation machinery can lead to pathology. Single-molecule live-cell imaging techniques have revealed unique features of this journey with unprecedented resolution. In this review, we highlight key recent findings that have been made using these approaches and possible implications for spatial control of gene function.

Original languageEnglish (US)
Pages (from-to)38-46
Number of pages9
JournalCurrent Opinion in Cell Biology
Volume45
DOIs
StatePublished - Apr 1 2017

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Cell Biology
RNA Transport
Messenger RNA
Gene Expression Regulation
Eukaryota
Cytoplasm
Yeasts
RNA
Pathology
Neurons
Genes
Proteins

ASJC Scopus subject areas

  • Cell Biology

Cite this

RNP transport in cell biology : the long and winding road. / Eliscovich, Carolina; Singer, Robert H.

In: Current Opinion in Cell Biology, Vol. 45, 01.04.2017, p. 38-46.

Research output: Contribution to journalReview article

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