RNP localization and transport in yeast

P. Chartrand, Robert H. Singer, R. M. Long

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The localization of mRNAs is used by various types of polarized cells to locally translate specific proteins, which restricts their distribution to a particular sub-region of the cytoplasm. This mechanism of protein sorting is involved in major biological processes such as asymmetric cell division, oogenesis, cellular motility, and synapse formation. With the finding of localized mRNAs in the yeast Saccharomyces cerevisiae, it is now possible to benefit from the powerful yeast laboratory tools to explore the molecular basis of RNA localization. Because mRNA transport and localization in yeast share many features with RNA localization in higher eukaryotes, including the formation of a large ribonucleoprotein (RNP) localization complex, the requirement of a polarized cytoskeleton and molecular motors, and the role of nuclear RNA-binding proteins in cytoplasmic localization, the yeast can be used as a paradigm for unraveling the molecular aspects of this process. This review summarizes the current knowledge on RNP transport and localization in yeast.

Original languageEnglish (US)
Pages (from-to)297-310
Number of pages14
JournalAnnual Review of Cell and Developmental Biology
Volume17
DOIs
StatePublished - 2001

Fingerprint

Ribonucleoproteins
Yeasts
Messenger RNA
Asymmetric Cell Division
RNA
Biological Phenomena
Nuclear RNA
Oogenesis
RNA-Binding Proteins
Protein Transport
Nuclear Proteins
Eukaryota
Cytoskeleton
Synapses
Saccharomyces cerevisiae
Cytoplasm
Proteins

Keywords

  • ASH1 mRNA
  • Locasome
  • Myosin
  • RNA localization
  • She proteins

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

RNP localization and transport in yeast. / Chartrand, P.; Singer, Robert H.; Long, R. M.

In: Annual Review of Cell and Developmental Biology, Vol. 17, 2001, p. 297-310.

Research output: Contribution to journalArticle

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