RNA processing and export.

Sami Hocine, Robert H. Singer, David Grünwald

Research output: Contribution to journalReview articlepeer-review

84 Scopus citations

Abstract

Messenger RNAs undergo 5' capping, splicing, 3'-end processing, and export before translation in the cytoplasm. It has become clear that these mRNA processing events are tightly coupled and have a profound effect on the fate of the resulting transcript. This processing is represented by modifications of the pre-mRNA and loading of various protein factors. The sum of protein factors that stay with the mRNA as a result of processing is modified over the life of the transcript, conferring significant regulation to its expression.

Original languageEnglish (US)
Pages (from-to)a000752
JournalCold Spring Harbor Perspectives in Biology
Volume2
Issue number12
DOIs
StatePublished - Dec 1 2010

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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