RNA processing and export.

Sami Hocine; Robert H. Singer; David Grünwald

doi:10.1101/cshperspect.a000752

RNA processing and export.

Sami Hocine, Robert H. Singer, David Grünwald

Research output: Contribution to journal › Review article › peer-review

128 Scopus citations

Abstract

Messenger RNAs undergo 5' capping, splicing, 3'-end processing, and export before translation in the cytoplasm. It has become clear that these mRNA processing events are tightly coupled and have a profound effect on the fate of the resulting transcript. This processing is represented by modifications of the pre-mRNA and loading of various protein factors. The sum of protein factors that stay with the mRNA as a result of processing is modified over the life of the transcript, conferring significant regulation to its expression.

Original language	English (US)
Pages (from-to)	a000752
Journal	Cold Spring Harbor Perspectives in Biology
Volume	2
Issue number	12
DOIs	https://doi.org/10.1101/cshperspect.a000752
State	Published - Dec 1 2010
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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AU - Grünwald, David

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AB - Messenger RNAs undergo 5' capping, splicing, 3'-end processing, and export before translation in the cytoplasm. It has become clear that these mRNA processing events are tightly coupled and have a profound effect on the fate of the resulting transcript. This processing is represented by modifications of the pre-mRNA and loading of various protein factors. The sum of protein factors that stay with the mRNA as a result of processing is modified over the life of the transcript, conferring significant regulation to its expression.

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RNA processing and export.

Abstract

ASJC Scopus subject areas

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