RNA processing and export.

Sami Hocine, Robert H. Singer, David Grünwald

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Messenger RNAs undergo 5' capping, splicing, 3'-end processing, and export before translation in the cytoplasm. It has become clear that these mRNA processing events are tightly coupled and have a profound effect on the fate of the resulting transcript. This processing is represented by modifications of the pre-mRNA and loading of various protein factors. The sum of protein factors that stay with the mRNA as a result of processing is modified over the life of the transcript, conferring significant regulation to its expression.

Original languageEnglish (US)
JournalCold Spring Harbor perspectives in biology
Volume2
Issue number12
StatePublished - Dec 1 2010
Externally publishedYes

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RNA
Messenger RNA
Processing
RNA Precursors
Cytoplasm
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

RNA processing and export. / Hocine, Sami; Singer, Robert H.; Grünwald, David.

In: Cold Spring Harbor perspectives in biology, Vol. 2, No. 12, 01.12.2010.

Research output: Contribution to journalArticle

Hocine, Sami ; Singer, Robert H. ; Grünwald, David. / RNA processing and export. In: Cold Spring Harbor perspectives in biology. 2010 ; Vol. 2, No. 12.
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