RNA localization: Different zipcodes, same postman?

Yuri Oleynikov, Robert H. Singer

Research output: Contribution to journalArticle

106 Scopus citations

Abstract

RNA-localization mechansims involve specific sequences in the localized RNA and proteins that bind to these sequences and mediate the interaction with cytoskeletal elements. Until recently, it seemed as thought two separate types of mechanism were operating for mRNA localization - involving interaction with either microtubules or actin microfilaments. However, it is now clear that some of the protein components involved in mRNA localization can participate in both microtubule- and actin-dependent localization pathways. This, combined with new evidence for evolutionary conservation of some of these proteins, suggests a previously unanticipated uniformity in mRNA-localization mechanisms.

Original languageEnglish (US)
Pages (from-to)381-383
Number of pages3
JournalTrends in Cell Biology
Volume8
Issue number10
DOIs
StatePublished - Oct 1 1998

ASJC Scopus subject areas

  • Cell Biology

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