TY - JOUR
T1 - RNA asymmetric distribution and daughter/mother differentiation in yeast
AU - Darzacq, Xavier
AU - Powrie, Erin
AU - Gu, Wei
AU - Singer, Robert H.
AU - Zenklusen, Daniel
N1 - Funding Information:
We thank Kelly Shepard for sharing results before publication. The research carried in our laboratory is supported by the NIH grant GM57071.
PY - 2003/12
Y1 - 2003/12
N2 - Active transport and localized translation of the ASH1 mRNA at the bud tip of the budding yeast Saccharomyces cerevisiae is an essential process that is required for the regulation of the mating type switching. ASH1 mRNA localization has been extensively studied over the past few years and the core components of the translocation machinery have been identified. It is composed of four localization elements (zipcodes), within the ASH1 mRNA, and at least three proteins, She1p/Myo4p, She2p and She3p. Whereas the movement of the RNA can be attributed to direct interaction with myosin, the regulation of the RNA expression is less well understood. Recent insights have revealed a role for translation that might have a key function in the regulation of Ash1 protein sorting.
AB - Active transport and localized translation of the ASH1 mRNA at the bud tip of the budding yeast Saccharomyces cerevisiae is an essential process that is required for the regulation of the mating type switching. ASH1 mRNA localization has been extensively studied over the past few years and the core components of the translocation machinery have been identified. It is composed of four localization elements (zipcodes), within the ASH1 mRNA, and at least three proteins, She1p/Myo4p, She2p and She3p. Whereas the movement of the RNA can be attributed to direct interaction with myosin, the regulation of the RNA expression is less well understood. Recent insights have revealed a role for translation that might have a key function in the regulation of Ash1 protein sorting.
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U2 - 10.1016/j.mib.2003.10.005
DO - 10.1016/j.mib.2003.10.005
M3 - Review article
C2 - 14662358
AN - SCOPUS:0346103753
SN - 1369-5274
VL - 6
SP - 614
EP - 620
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
IS - 6
ER -