RNA asymmetric distribution and daughter/mother differentiation in yeast

Xavier Darzacq, Erin Powrie, Wei Gu, Robert H. Singer, Daniel Zenklusen

Research output: Contribution to journalReview article

38 Scopus citations

Abstract

Active transport and localized translation of the ASH1 mRNA at the bud tip of the budding yeast Saccharomyces cerevisiae is an essential process that is required for the regulation of the mating type switching. ASH1 mRNA localization has been extensively studied over the past few years and the core components of the translocation machinery have been identified. It is composed of four localization elements (zipcodes), within the ASH1 mRNA, and at least three proteins, She1p/Myo4p, She2p and She3p. Whereas the movement of the RNA can be attributed to direct interaction with myosin, the regulation of the RNA expression is less well understood. Recent insights have revealed a role for translation that might have a key function in the regulation of Ash1 protein sorting.

Original languageEnglish (US)
Pages (from-to)614-620
Number of pages7
JournalCurrent Opinion in Microbiology
Volume6
Issue number6
DOIs
StatePublished - Dec 2003

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ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

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