Risk of Pulmonary Embolism after Cerebral Venous Thrombosis

Ava Leigh Liberman, Alexander E. Merkler, Gino Gialdini, Steven R. Messé, Michael P. Lerario, Santosh B. Murthy, Hooman Kamel, Babak B. Navi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background and Purpose - Cerebral vein thrombosis (CVT) is a type of venous thromboembolism. Whether the risk of pulmonary embolism (PE) after CVT is similar to the risk after deep venous thrombosis (DVT) is unknown. Methods - We performed a retrospective cohort study using administrative data from all emergency department visits and hospitalizations in California, New York, and Florida from 2005 to 2013. We identified patients with CVT or DVT and the outcome of PE using previously validated International Classification of Diseases, Ninth Revision, Clinical Modification codes. Kaplan-Meier survival statistics and Cox proportional hazards models were used to compare the risk of PE after CVT versus PE after DVT. Results - We identified 4754 patients with CVT and 241 276 with DVT. During a mean follow-up of 3.4 (±2.4) years, 138 patients with CVT and 23 063 with DVT developed PE. CVT patients were younger, more often female, and had fewer risk factors for thromboembolism than patients with DVT. During the index hospitalization, the rate of PE was 1.4% (95% confidence interval [CI], 1.1%-1.8%) in patients with CVT and 6.6% (95% CI, 6.5%-6.7%) in patients with DVT. By 5 years, the cumulative rate of PE after CVT was 3.4% (95% CI, 2.9%-4.0%) compared with 10.9% (95% CI, 10.8%-11.0%; P<0.001) after DVT. CVT was associated with a lower adjusted hazard of PE than DVT (hazard ratio, 0.26; 95% CI, 0.22-0.31). Conclusion - The risk of PE after CVT was significantly lower than the risk after DVT. Among patients with CVT, the greatest risk for PE was during the index hospitalization.

Original languageEnglish (US)
Pages (from-to)563-567
Number of pages5
JournalStroke
Volume48
Issue number3
DOIs
StatePublished - Mar 1 2017

Fingerprint

Cerebral Veins
Intracranial Thrombosis
Pulmonary Embolism
Venous Thrombosis
Confidence Intervals
Hospitalization
Thromboembolism
Venous Thromboembolism
International Classification of Diseases
Proportional Hazards Models
Hospital Emergency Service

Keywords

  • cerebral venous thrombosis
  • deep vein thrombosis
  • pulmonary embolism
  • thrombosis
  • venous thromboembolism

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

Liberman, A. L., Merkler, A. E., Gialdini, G., Messé, S. R., Lerario, M. P., Murthy, S. B., ... Navi, B. B. (2017). Risk of Pulmonary Embolism after Cerebral Venous Thrombosis. Stroke, 48(3), 563-567. https://doi.org/10.1161/STROKEAHA.116.016316

Risk of Pulmonary Embolism after Cerebral Venous Thrombosis. / Liberman, Ava Leigh; Merkler, Alexander E.; Gialdini, Gino; Messé, Steven R.; Lerario, Michael P.; Murthy, Santosh B.; Kamel, Hooman; Navi, Babak B.

In: Stroke, Vol. 48, No. 3, 01.03.2017, p. 563-567.

Research output: Contribution to journalArticle

Liberman, AL, Merkler, AE, Gialdini, G, Messé, SR, Lerario, MP, Murthy, SB, Kamel, H & Navi, BB 2017, 'Risk of Pulmonary Embolism after Cerebral Venous Thrombosis', Stroke, vol. 48, no. 3, pp. 563-567. https://doi.org/10.1161/STROKEAHA.116.016316
Liberman AL, Merkler AE, Gialdini G, Messé SR, Lerario MP, Murthy SB et al. Risk of Pulmonary Embolism after Cerebral Venous Thrombosis. Stroke. 2017 Mar 1;48(3):563-567. https://doi.org/10.1161/STROKEAHA.116.016316
Liberman, Ava Leigh ; Merkler, Alexander E. ; Gialdini, Gino ; Messé, Steven R. ; Lerario, Michael P. ; Murthy, Santosh B. ; Kamel, Hooman ; Navi, Babak B. / Risk of Pulmonary Embolism after Cerebral Venous Thrombosis. In: Stroke. 2017 ; Vol. 48, No. 3. pp. 563-567.
@article{ec043eea75664d578446e33bcd4a673b,
title = "Risk of Pulmonary Embolism after Cerebral Venous Thrombosis",
abstract = "Background and Purpose - Cerebral vein thrombosis (CVT) is a type of venous thromboembolism. Whether the risk of pulmonary embolism (PE) after CVT is similar to the risk after deep venous thrombosis (DVT) is unknown. Methods - We performed a retrospective cohort study using administrative data from all emergency department visits and hospitalizations in California, New York, and Florida from 2005 to 2013. We identified patients with CVT or DVT and the outcome of PE using previously validated International Classification of Diseases, Ninth Revision, Clinical Modification codes. Kaplan-Meier survival statistics and Cox proportional hazards models were used to compare the risk of PE after CVT versus PE after DVT. Results - We identified 4754 patients with CVT and 241 276 with DVT. During a mean follow-up of 3.4 (±2.4) years, 138 patients with CVT and 23 063 with DVT developed PE. CVT patients were younger, more often female, and had fewer risk factors for thromboembolism than patients with DVT. During the index hospitalization, the rate of PE was 1.4{\%} (95{\%} confidence interval [CI], 1.1{\%}-1.8{\%}) in patients with CVT and 6.6{\%} (95{\%} CI, 6.5{\%}-6.7{\%}) in patients with DVT. By 5 years, the cumulative rate of PE after CVT was 3.4{\%} (95{\%} CI, 2.9{\%}-4.0{\%}) compared with 10.9{\%} (95{\%} CI, 10.8{\%}-11.0{\%}; P<0.001) after DVT. CVT was associated with a lower adjusted hazard of PE than DVT (hazard ratio, 0.26; 95{\%} CI, 0.22-0.31). Conclusion - The risk of PE after CVT was significantly lower than the risk after DVT. Among patients with CVT, the greatest risk for PE was during the index hospitalization.",
keywords = "cerebral venous thrombosis, deep vein thrombosis, pulmonary embolism, thrombosis, venous thromboembolism",
author = "Liberman, {Ava Leigh} and Merkler, {Alexander E.} and Gino Gialdini and Mess{\'e}, {Steven R.} and Lerario, {Michael P.} and Murthy, {Santosh B.} and Hooman Kamel and Navi, {Babak B.}",
year = "2017",
month = "3",
day = "1",
doi = "10.1161/STROKEAHA.116.016316",
language = "English (US)",
volume = "48",
pages = "563--567",
journal = "Stroke",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Risk of Pulmonary Embolism after Cerebral Venous Thrombosis

AU - Liberman, Ava Leigh

AU - Merkler, Alexander E.

AU - Gialdini, Gino

AU - Messé, Steven R.

AU - Lerario, Michael P.

AU - Murthy, Santosh B.

AU - Kamel, Hooman

AU - Navi, Babak B.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Background and Purpose - Cerebral vein thrombosis (CVT) is a type of venous thromboembolism. Whether the risk of pulmonary embolism (PE) after CVT is similar to the risk after deep venous thrombosis (DVT) is unknown. Methods - We performed a retrospective cohort study using administrative data from all emergency department visits and hospitalizations in California, New York, and Florida from 2005 to 2013. We identified patients with CVT or DVT and the outcome of PE using previously validated International Classification of Diseases, Ninth Revision, Clinical Modification codes. Kaplan-Meier survival statistics and Cox proportional hazards models were used to compare the risk of PE after CVT versus PE after DVT. Results - We identified 4754 patients with CVT and 241 276 with DVT. During a mean follow-up of 3.4 (±2.4) years, 138 patients with CVT and 23 063 with DVT developed PE. CVT patients were younger, more often female, and had fewer risk factors for thromboembolism than patients with DVT. During the index hospitalization, the rate of PE was 1.4% (95% confidence interval [CI], 1.1%-1.8%) in patients with CVT and 6.6% (95% CI, 6.5%-6.7%) in patients with DVT. By 5 years, the cumulative rate of PE after CVT was 3.4% (95% CI, 2.9%-4.0%) compared with 10.9% (95% CI, 10.8%-11.0%; P<0.001) after DVT. CVT was associated with a lower adjusted hazard of PE than DVT (hazard ratio, 0.26; 95% CI, 0.22-0.31). Conclusion - The risk of PE after CVT was significantly lower than the risk after DVT. Among patients with CVT, the greatest risk for PE was during the index hospitalization.

AB - Background and Purpose - Cerebral vein thrombosis (CVT) is a type of venous thromboembolism. Whether the risk of pulmonary embolism (PE) after CVT is similar to the risk after deep venous thrombosis (DVT) is unknown. Methods - We performed a retrospective cohort study using administrative data from all emergency department visits and hospitalizations in California, New York, and Florida from 2005 to 2013. We identified patients with CVT or DVT and the outcome of PE using previously validated International Classification of Diseases, Ninth Revision, Clinical Modification codes. Kaplan-Meier survival statistics and Cox proportional hazards models were used to compare the risk of PE after CVT versus PE after DVT. Results - We identified 4754 patients with CVT and 241 276 with DVT. During a mean follow-up of 3.4 (±2.4) years, 138 patients with CVT and 23 063 with DVT developed PE. CVT patients were younger, more often female, and had fewer risk factors for thromboembolism than patients with DVT. During the index hospitalization, the rate of PE was 1.4% (95% confidence interval [CI], 1.1%-1.8%) in patients with CVT and 6.6% (95% CI, 6.5%-6.7%) in patients with DVT. By 5 years, the cumulative rate of PE after CVT was 3.4% (95% CI, 2.9%-4.0%) compared with 10.9% (95% CI, 10.8%-11.0%; P<0.001) after DVT. CVT was associated with a lower adjusted hazard of PE than DVT (hazard ratio, 0.26; 95% CI, 0.22-0.31). Conclusion - The risk of PE after CVT was significantly lower than the risk after DVT. Among patients with CVT, the greatest risk for PE was during the index hospitalization.

KW - cerebral venous thrombosis

KW - deep vein thrombosis

KW - pulmonary embolism

KW - thrombosis

KW - venous thromboembolism

UR - http://www.scopus.com/inward/record.url?scp=85013639976&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85013639976&partnerID=8YFLogxK

U2 - 10.1161/STROKEAHA.116.016316

DO - 10.1161/STROKEAHA.116.016316

M3 - Article

VL - 48

SP - 563

EP - 567

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 3

ER -