Risk factors for squamous intraepithelial lesions on pap smear in women at risk for human immunodeficiency virus infection

Robert S. Klein, Gloria Y F Ho, Sten H. Vermund, Irene Fleming, Robert D. Burk

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

To determine risk factors for squamous intraepithelial lesions (SIL) on Pap smear, 253 women at risk for human immunodeficiency virus (HIV) infection had Pap smear, HIV antibody testing, CD4+ cell measurements, and human papillomavirus (HPV) genome detection by Southern blot hybridization. Associated with SIL (P < .05) on univariate analysis were genital HPV (SIL prevalence in HPV-positive subjects, 36.3%; odds ratio [OR], 9.3; 95% confidence interval [CI], 4.2-20.3) and HIV infection (SIL prevalence in seropositive subjects, 21.9%; OR, 2.5; 95% CI, 1.2-5.1). No demographic or behavioral variables were associated with risk for SIL. Multivariate analyses identified genital HPV infection (OR, 6.78; 95% CI, 2.9-15.7), detection of known high-risk HPV types (OR, 11.8; 95% CI, 4.1-34.1), strong HPV Southern blot signal strength (OR, 10.8; 95% CI, 3.5-33.7), and severe HIV-related immunosuppression (OR, 3.1; 95% CI, 1.04-9.5) as independent risk factors associated with SIL. Thus, severe immunosuppression due to HIV infection increases the risk for SIL mediated by HPV infection.

Original languageEnglish (US)
Pages (from-to)1404-1409
Number of pages6
JournalJournal of Infectious Diseases
Volume170
Issue number6
StatePublished - Dec 1994

Fingerprint

Papanicolaou Test
Virus Diseases
HIV
Odds Ratio
Confidence Intervals
Papillomavirus Infections
Southern Blotting
Immunosuppression
Human Genome
Squamous Intraepithelial Lesions of the Cervix
Multivariate Analysis
Demography
Antibodies

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Risk factors for squamous intraepithelial lesions on pap smear in women at risk for human immunodeficiency virus infection. / Klein, Robert S.; Ho, Gloria Y F; Vermund, Sten H.; Fleming, Irene; Burk, Robert D.

In: Journal of Infectious Diseases, Vol. 170, No. 6, 12.1994, p. 1404-1409.

Research output: Contribution to journalArticle

Klein, Robert S. ; Ho, Gloria Y F ; Vermund, Sten H. ; Fleming, Irene ; Burk, Robert D. / Risk factors for squamous intraepithelial lesions on pap smear in women at risk for human immunodeficiency virus infection. In: Journal of Infectious Diseases. 1994 ; Vol. 170, No. 6. pp. 1404-1409.
@article{e09f81ad2b0c4ad38e26ee0362cef5b3,
title = "Risk factors for squamous intraepithelial lesions on pap smear in women at risk for human immunodeficiency virus infection",
abstract = "To determine risk factors for squamous intraepithelial lesions (SIL) on Pap smear, 253 women at risk for human immunodeficiency virus (HIV) infection had Pap smear, HIV antibody testing, CD4+ cell measurements, and human papillomavirus (HPV) genome detection by Southern blot hybridization. Associated with SIL (P < .05) on univariate analysis were genital HPV (SIL prevalence in HPV-positive subjects, 36.3{\%}; odds ratio [OR], 9.3; 95{\%} confidence interval [CI], 4.2-20.3) and HIV infection (SIL prevalence in seropositive subjects, 21.9{\%}; OR, 2.5; 95{\%} CI, 1.2-5.1). No demographic or behavioral variables were associated with risk for SIL. Multivariate analyses identified genital HPV infection (OR, 6.78; 95{\%} CI, 2.9-15.7), detection of known high-risk HPV types (OR, 11.8; 95{\%} CI, 4.1-34.1), strong HPV Southern blot signal strength (OR, 10.8; 95{\%} CI, 3.5-33.7), and severe HIV-related immunosuppression (OR, 3.1; 95{\%} CI, 1.04-9.5) as independent risk factors associated with SIL. Thus, severe immunosuppression due to HIV infection increases the risk for SIL mediated by HPV infection.",
author = "Klein, {Robert S.} and Ho, {Gloria Y F} and Vermund, {Sten H.} and Irene Fleming and Burk, {Robert D.}",
year = "1994",
month = "12",
language = "English (US)",
volume = "170",
pages = "1404--1409",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "6",

}

TY - JOUR

T1 - Risk factors for squamous intraepithelial lesions on pap smear in women at risk for human immunodeficiency virus infection

AU - Klein, Robert S.

AU - Ho, Gloria Y F

AU - Vermund, Sten H.

AU - Fleming, Irene

AU - Burk, Robert D.

PY - 1994/12

Y1 - 1994/12

N2 - To determine risk factors for squamous intraepithelial lesions (SIL) on Pap smear, 253 women at risk for human immunodeficiency virus (HIV) infection had Pap smear, HIV antibody testing, CD4+ cell measurements, and human papillomavirus (HPV) genome detection by Southern blot hybridization. Associated with SIL (P < .05) on univariate analysis were genital HPV (SIL prevalence in HPV-positive subjects, 36.3%; odds ratio [OR], 9.3; 95% confidence interval [CI], 4.2-20.3) and HIV infection (SIL prevalence in seropositive subjects, 21.9%; OR, 2.5; 95% CI, 1.2-5.1). No demographic or behavioral variables were associated with risk for SIL. Multivariate analyses identified genital HPV infection (OR, 6.78; 95% CI, 2.9-15.7), detection of known high-risk HPV types (OR, 11.8; 95% CI, 4.1-34.1), strong HPV Southern blot signal strength (OR, 10.8; 95% CI, 3.5-33.7), and severe HIV-related immunosuppression (OR, 3.1; 95% CI, 1.04-9.5) as independent risk factors associated with SIL. Thus, severe immunosuppression due to HIV infection increases the risk for SIL mediated by HPV infection.

AB - To determine risk factors for squamous intraepithelial lesions (SIL) on Pap smear, 253 women at risk for human immunodeficiency virus (HIV) infection had Pap smear, HIV antibody testing, CD4+ cell measurements, and human papillomavirus (HPV) genome detection by Southern blot hybridization. Associated with SIL (P < .05) on univariate analysis were genital HPV (SIL prevalence in HPV-positive subjects, 36.3%; odds ratio [OR], 9.3; 95% confidence interval [CI], 4.2-20.3) and HIV infection (SIL prevalence in seropositive subjects, 21.9%; OR, 2.5; 95% CI, 1.2-5.1). No demographic or behavioral variables were associated with risk for SIL. Multivariate analyses identified genital HPV infection (OR, 6.78; 95% CI, 2.9-15.7), detection of known high-risk HPV types (OR, 11.8; 95% CI, 4.1-34.1), strong HPV Southern blot signal strength (OR, 10.8; 95% CI, 3.5-33.7), and severe HIV-related immunosuppression (OR, 3.1; 95% CI, 1.04-9.5) as independent risk factors associated with SIL. Thus, severe immunosuppression due to HIV infection increases the risk for SIL mediated by HPV infection.

UR - http://www.scopus.com/inward/record.url?scp=0028035157&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028035157&partnerID=8YFLogxK

M3 - Article

VL - 170

SP - 1404

EP - 1409

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 6

ER -