Risk factors for fibroadenoma

A case-control study in Australia

He Yu, Thomas E. Rohan, Martin G. Cook, Geoffrey R. Howe, Anthony B. Miller

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Risk factors for fibroadenoma were examined in a case-control study involving 117 fibroadenoma cases ascertained by a major private pathology laboratory in Adelaide, Australia, between January 1983 and October 1985. For each case a population control was randomly selected from the electoral roll in Adelaide and matched to the corresponding case by sex, age, and socioeconomic grading of area of residence. Another 189 women whose first biopsy for benign breast disease was examined in the same laboratory during the same time period as those of the cases, but did not show evidence of epithelial proliferation, were also included in the study as a biopsy control group. Risk of fibroadenoma was associated inversely with the Quetelet index, but there was no evidence of an association with age at menarche or menopausal status. The risk of fibroadenoma decreased with an increasing number of full-term pregnancies and was increased in association with use of oral contraceptives at an early age (under 20 years); however, these two associations were observed only when cases were compared with the population controls. Alcohol consumption and dietary fat intake were found not to be associated with altered risk of fibroadenoma, while in multivariate analyses, duration of cigarette smoking and daily vitamin C intake were both shown to have inverse associations with risk of fibroadenoma. Although fibroadenoma does share some risk factors with breast cancer, there is insufficient evidence to suggest that it represents a precursor state. Am J Epidemiol 1992;135:247-58.

Original languageEnglish (US)
Pages (from-to)247-258
Number of pages12
JournalAmerican Journal of Epidemiology
Volume135
Issue number3
StatePublished - Feb 1 1992
Externally publishedYes

Fingerprint

Fibroadenoma
Case-Control Studies
Population Control
Biopsy
Breast Diseases
Menarche
Dietary Fats
Oral Contraceptives
Alcohol Drinking
Ascorbic Acid
Body Mass Index
Multivariate Analysis
Smoking
Pathology
Breast Neoplasms
Pregnancy
Control Groups

Keywords

  • Breast diseases
  • Case-control studies
  • Risk factors

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Epidemiology

Cite this

Yu, H., Rohan, T. E., Cook, M. G., Howe, G. R., & Miller, A. B. (1992). Risk factors for fibroadenoma: A case-control study in Australia. American Journal of Epidemiology, 135(3), 247-258.

Risk factors for fibroadenoma : A case-control study in Australia. / Yu, He; Rohan, Thomas E.; Cook, Martin G.; Howe, Geoffrey R.; Miller, Anthony B.

In: American Journal of Epidemiology, Vol. 135, No. 3, 01.02.1992, p. 247-258.

Research output: Contribution to journalArticle

Yu, H, Rohan, TE, Cook, MG, Howe, GR & Miller, AB 1992, 'Risk factors for fibroadenoma: A case-control study in Australia', American Journal of Epidemiology, vol. 135, no. 3, pp. 247-258.
Yu, He ; Rohan, Thomas E. ; Cook, Martin G. ; Howe, Geoffrey R. ; Miller, Anthony B. / Risk factors for fibroadenoma : A case-control study in Australia. In: American Journal of Epidemiology. 1992 ; Vol. 135, No. 3. pp. 247-258.
@article{e7faa38701e5407aa3b2c647b62af696,
title = "Risk factors for fibroadenoma: A case-control study in Australia",
abstract = "Risk factors for fibroadenoma were examined in a case-control study involving 117 fibroadenoma cases ascertained by a major private pathology laboratory in Adelaide, Australia, between January 1983 and October 1985. For each case a population control was randomly selected from the electoral roll in Adelaide and matched to the corresponding case by sex, age, and socioeconomic grading of area of residence. Another 189 women whose first biopsy for benign breast disease was examined in the same laboratory during the same time period as those of the cases, but did not show evidence of epithelial proliferation, were also included in the study as a biopsy control group. Risk of fibroadenoma was associated inversely with the Quetelet index, but there was no evidence of an association with age at menarche or menopausal status. The risk of fibroadenoma decreased with an increasing number of full-term pregnancies and was increased in association with use of oral contraceptives at an early age (under 20 years); however, these two associations were observed only when cases were compared with the population controls. Alcohol consumption and dietary fat intake were found not to be associated with altered risk of fibroadenoma, while in multivariate analyses, duration of cigarette smoking and daily vitamin C intake were both shown to have inverse associations with risk of fibroadenoma. Although fibroadenoma does share some risk factors with breast cancer, there is insufficient evidence to suggest that it represents a precursor state. Am J Epidemiol 1992;135:247-58.",
keywords = "Breast diseases, Case-control studies, Risk factors",
author = "He Yu and Rohan, {Thomas E.} and Cook, {Martin G.} and Howe, {Geoffrey R.} and Miller, {Anthony B.}",
year = "1992",
month = "2",
day = "1",
language = "English (US)",
volume = "135",
pages = "247--258",
journal = "American Journal of Epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "3",

}

TY - JOUR

T1 - Risk factors for fibroadenoma

T2 - A case-control study in Australia

AU - Yu, He

AU - Rohan, Thomas E.

AU - Cook, Martin G.

AU - Howe, Geoffrey R.

AU - Miller, Anthony B.

PY - 1992/2/1

Y1 - 1992/2/1

N2 - Risk factors for fibroadenoma were examined in a case-control study involving 117 fibroadenoma cases ascertained by a major private pathology laboratory in Adelaide, Australia, between January 1983 and October 1985. For each case a population control was randomly selected from the electoral roll in Adelaide and matched to the corresponding case by sex, age, and socioeconomic grading of area of residence. Another 189 women whose first biopsy for benign breast disease was examined in the same laboratory during the same time period as those of the cases, but did not show evidence of epithelial proliferation, were also included in the study as a biopsy control group. Risk of fibroadenoma was associated inversely with the Quetelet index, but there was no evidence of an association with age at menarche or menopausal status. The risk of fibroadenoma decreased with an increasing number of full-term pregnancies and was increased in association with use of oral contraceptives at an early age (under 20 years); however, these two associations were observed only when cases were compared with the population controls. Alcohol consumption and dietary fat intake were found not to be associated with altered risk of fibroadenoma, while in multivariate analyses, duration of cigarette smoking and daily vitamin C intake were both shown to have inverse associations with risk of fibroadenoma. Although fibroadenoma does share some risk factors with breast cancer, there is insufficient evidence to suggest that it represents a precursor state. Am J Epidemiol 1992;135:247-58.

AB - Risk factors for fibroadenoma were examined in a case-control study involving 117 fibroadenoma cases ascertained by a major private pathology laboratory in Adelaide, Australia, between January 1983 and October 1985. For each case a population control was randomly selected from the electoral roll in Adelaide and matched to the corresponding case by sex, age, and socioeconomic grading of area of residence. Another 189 women whose first biopsy for benign breast disease was examined in the same laboratory during the same time period as those of the cases, but did not show evidence of epithelial proliferation, were also included in the study as a biopsy control group. Risk of fibroadenoma was associated inversely with the Quetelet index, but there was no evidence of an association with age at menarche or menopausal status. The risk of fibroadenoma decreased with an increasing number of full-term pregnancies and was increased in association with use of oral contraceptives at an early age (under 20 years); however, these two associations were observed only when cases were compared with the population controls. Alcohol consumption and dietary fat intake were found not to be associated with altered risk of fibroadenoma, while in multivariate analyses, duration of cigarette smoking and daily vitamin C intake were both shown to have inverse associations with risk of fibroadenoma. Although fibroadenoma does share some risk factors with breast cancer, there is insufficient evidence to suggest that it represents a precursor state. Am J Epidemiol 1992;135:247-58.

KW - Breast diseases

KW - Case-control studies

KW - Risk factors

UR - http://www.scopus.com/inward/record.url?scp=0026547793&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026547793&partnerID=8YFLogxK

M3 - Article

VL - 135

SP - 247

EP - 258

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 3

ER -