Risk factors for acquisition and clearance of oral human papillomavirus infection among HIV-infected and HIV-uninfected adults

Daniel C. Beachler, Elizabeth A. Sugar, Joseph B. Margolick, Kathleen M. Weber, Howard Strickler, Dorothy J. Wiley, Ross D. Cranston, Robert D. Burk, Howard Minkoff, Susheel Reddy, Weihong Xiao, Yingshi Guo, Maura L. Gillison, Gypsyamber D'Souza

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Human papillomavirus (HPV) causes the majority of oropharyngeal cancers in the United States, yet the risk factors for and natural history of oral HPV infection are largely unknown. In 2010-2011, a US-based longitudinal cohort study of 761 human immunodeficiency virus (HIV)-infected and 469 at-risk HIV-uninfected participants from the Multicenter AIDS Cohort Study and the Women's Interagency HIV Study was initiated. Semiannually collected oral rinses were evaluated for 37 HPV genotypes using the Roche LINEAR ARRAY HPV Genotyping Test (Roche Molecular Systems, Pleasanton, California), and factors associated with oral HPV incidence and clearance were explored using adjusted Wei-Lin-Weissfeld modeling. Through 2013, the 2-year cumulative incidence of any type of oral HPV infection was 34% in HIV-infected persons and 19% in HIV-uninfected persons. However, many of these infections cleared. Seven percent of incident infections and 35% of prevalent infections persisted for at least 2 years. After adjustment for other risk factors, HIV infection (adjusted hazard ratio = 2.3, 95% confidence interval: 1.7, 3.2), reduced current CD4 cell count, and increased numbers of oral sex and "rimming" partners increased the risk of incident oral HPV infection, whereas male sex, older age, and current smoking increased the risk of oral HPV persistence (each P < 0.05). This helps explain the consistent associations observed between these factors and prevalent oral HPV infection in previous cross-sectional studies.

Original languageEnglish (US)
Pages (from-to)40-53
Number of pages14
JournalAmerican Journal of Epidemiology
Volume181
Issue number1
DOIs
StatePublished - Jan 1 2015

Fingerprint

Papillomavirus Infections
HIV
Cohort Studies
Infection
Oropharyngeal Neoplasms
Incidence
Virus Diseases
CD4 Lymphocyte Count
Natural History
Sexual Behavior
Longitudinal Studies
Acquired Immunodeficiency Syndrome
Cross-Sectional Studies
Smoking
Genotype
Confidence Intervals

Keywords

  • Head and neck cancer
  • HIV
  • Human papillomavirus
  • Natural history
  • Oral HPV
  • Risk factors

ASJC Scopus subject areas

  • Epidemiology

Cite this

Risk factors for acquisition and clearance of oral human papillomavirus infection among HIV-infected and HIV-uninfected adults. / Beachler, Daniel C.; Sugar, Elizabeth A.; Margolick, Joseph B.; Weber, Kathleen M.; Strickler, Howard; Wiley, Dorothy J.; Cranston, Ross D.; Burk, Robert D.; Minkoff, Howard; Reddy, Susheel; Xiao, Weihong; Guo, Yingshi; Gillison, Maura L.; D'Souza, Gypsyamber.

In: American Journal of Epidemiology, Vol. 181, No. 1, 01.01.2015, p. 40-53.

Research output: Contribution to journalArticle

Beachler, DC, Sugar, EA, Margolick, JB, Weber, KM, Strickler, H, Wiley, DJ, Cranston, RD, Burk, RD, Minkoff, H, Reddy, S, Xiao, W, Guo, Y, Gillison, ML & D'Souza, G 2015, 'Risk factors for acquisition and clearance of oral human papillomavirus infection among HIV-infected and HIV-uninfected adults', American Journal of Epidemiology, vol. 181, no. 1, pp. 40-53. https://doi.org/10.1093/aje/kwu247
Beachler, Daniel C. ; Sugar, Elizabeth A. ; Margolick, Joseph B. ; Weber, Kathleen M. ; Strickler, Howard ; Wiley, Dorothy J. ; Cranston, Ross D. ; Burk, Robert D. ; Minkoff, Howard ; Reddy, Susheel ; Xiao, Weihong ; Guo, Yingshi ; Gillison, Maura L. ; D'Souza, Gypsyamber. / Risk factors for acquisition and clearance of oral human papillomavirus infection among HIV-infected and HIV-uninfected adults. In: American Journal of Epidemiology. 2015 ; Vol. 181, No. 1. pp. 40-53.
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