Ring chromosomes in dermatofibrosarcoma protuberans are composed of interspersed sequences from chromosomes 17 and 22

Rizwan C. Naeem, M. L. Lux, S. F. Huang, S. P. Naber, J. M. Corson, J. A. Fletcher

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

Ring chromosomes are found in most dermatofibrosarcoma protuberans (DFSPs), and recent reports demonstrate that portions of the DFSP ring chromosomes derive from chromosome 17. In this study we characterized ring chromosomes in three DFSPs using a combined approach of karyotyping, chromosome painting, and comparative genomic hybridization. Chromosome painting demonstrated that the ring chromosomes in each DFSP were composed of discontinuous, interwoven sequences from chromosomes 17 and 22. Amplification of chromosomes 17 and 22 sequences was confirmed in each of these cases by comparative genomic hybridization, and over-representation of chromosomes 17 and 22 sequences was also demonstrated by comparative genomic hybridization in 1 of 2 cytogenetically unremarkable DFSPs. We conclude that amplification of chromosomes 17 and 22 sequences, in ring form, is a characteristic aberration in DFSP.

Original languageEnglish (US)
Pages (from-to)1553-1558
Number of pages6
JournalAmerican Journal of Pathology
Volume147
Issue number6
StatePublished - 1995
Externally publishedYes

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Dermatofibrosarcoma
Ring Chromosomes
Chromosomes, Human, Pair 22
Chromosomes, Human, Pair 17
Comparative Genomic Hybridization
Chromosome Painting
Karyotyping

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Naeem, R. C., Lux, M. L., Huang, S. F., Naber, S. P., Corson, J. M., & Fletcher, J. A. (1995). Ring chromosomes in dermatofibrosarcoma protuberans are composed of interspersed sequences from chromosomes 17 and 22. American Journal of Pathology, 147(6), 1553-1558.

Ring chromosomes in dermatofibrosarcoma protuberans are composed of interspersed sequences from chromosomes 17 and 22. / Naeem, Rizwan C.; Lux, M. L.; Huang, S. F.; Naber, S. P.; Corson, J. M.; Fletcher, J. A.

In: American Journal of Pathology, Vol. 147, No. 6, 1995, p. 1553-1558.

Research output: Contribution to journalArticle

Naeem, Rizwan C. ; Lux, M. L. ; Huang, S. F. ; Naber, S. P. ; Corson, J. M. ; Fletcher, J. A. / Ring chromosomes in dermatofibrosarcoma protuberans are composed of interspersed sequences from chromosomes 17 and 22. In: American Journal of Pathology. 1995 ; Vol. 147, No. 6. pp. 1553-1558.
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