Right ventricular structure is associated with the risk of heart failure and cardiovascular death

The multi-ethnic study of atherosclerosis (MESA)-right ventricle study

Steven M. Kawut, R. Graham Barr, João A C Lima, Amy Praestgaard, W. Craig Johnson, Harjit Chahal, Kofo O. Ogunyankin, Michael R. Bristow, Jorge Kizer, Harikrishna Tandri, David A. Bluemke

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

BACKGROUND-: Changes in right ventricular (RV) morphology are associated with morbidity and mortality in heart and lung disease. We examined the association of abnormal RV structure and function with the risk of heart failure or cardiovascular death in a population-based multiethnic sample free of clinical cardiovascular disease at baseline. METHODS AND RESULTS-: The Multi-Ethnic Study of Atherosclerosis (MESA) performed cardiac magnetic resonance imaging on 5098 participants between 2000 and 2002 with follow-up for incident heart failure and cardiovascular death ("death") until January 2008. RV volumes and mass were available for 4204 participants. The study sample (n=4144) was 61.4±10.1 years old and 47.6% male. The presence of RV hypertrophy (increased RV mass) was associated with more than twice the risk of heart failure or death after adjustment for demographics, body mass index, education, C-reactive protein level, hypertension, and smoking status (hazard ratio, 2.52; 95% confidence interval, 1.55-4.10; P<0.001) and a doubling (or more) of risk with left ventricular mass at the mean value or lower (P for interaction=0.05). CONCLUSIONS-: RV hypertrophy was associated with the risk of heart failure or death in a multiethnic population free of clinical cardiovascular disease at baseline.

Original languageEnglish (US)
Pages (from-to)1681-1688
Number of pages8
JournalCirculation
Volume126
Issue number14
DOIs
StatePublished - Oct 2 2012
Externally publishedYes

Fingerprint

Heart Ventricles
Atherosclerosis
Heart Failure
Right Ventricular Hypertrophy
Cardiovascular Diseases
Right Ventricular Function
C-Reactive Protein
Population
Lung Diseases
Heart Diseases
Body Mass Index
Smoking
Magnetic Resonance Imaging
Demography
Confidence Intervals
Hypertension
Morbidity
Education
Mortality

Keywords

  • heart ventricles
  • hypertension, pulmonary
  • magnetic resonance imaging
  • pulmonary heart disease
  • survival

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Right ventricular structure is associated with the risk of heart failure and cardiovascular death : The multi-ethnic study of atherosclerosis (MESA)-right ventricle study. / Kawut, Steven M.; Barr, R. Graham; Lima, João A C; Praestgaard, Amy; Johnson, W. Craig; Chahal, Harjit; Ogunyankin, Kofo O.; Bristow, Michael R.; Kizer, Jorge; Tandri, Harikrishna; Bluemke, David A.

In: Circulation, Vol. 126, No. 14, 02.10.2012, p. 1681-1688.

Research output: Contribution to journalArticle

Kawut, SM, Barr, RG, Lima, JAC, Praestgaard, A, Johnson, WC, Chahal, H, Ogunyankin, KO, Bristow, MR, Kizer, J, Tandri, H & Bluemke, DA 2012, 'Right ventricular structure is associated with the risk of heart failure and cardiovascular death: The multi-ethnic study of atherosclerosis (MESA)-right ventricle study', Circulation, vol. 126, no. 14, pp. 1681-1688. https://doi.org/10.1161/CIRCULATIONAHA.112.095216
Kawut, Steven M. ; Barr, R. Graham ; Lima, João A C ; Praestgaard, Amy ; Johnson, W. Craig ; Chahal, Harjit ; Ogunyankin, Kofo O. ; Bristow, Michael R. ; Kizer, Jorge ; Tandri, Harikrishna ; Bluemke, David A. / Right ventricular structure is associated with the risk of heart failure and cardiovascular death : The multi-ethnic study of atherosclerosis (MESA)-right ventricle study. In: Circulation. 2012 ; Vol. 126, No. 14. pp. 1681-1688.
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