Right ventricular structure is associated with the risk of heart failure and cardiovascular death: The multi-ethnic study of atherosclerosis (MESA)-right ventricle study

Steven M. Kawut, R. Graham Barr, João A.C. Lima, Amy Praestgaard, W. Craig Johnson, Harjit Chahal, Kofo O. Ogunyankin, Michael R. Bristow, Jorge R. Kizer, Harikrishna Tandri, David A. Bluemke

Research output: Contribution to journalArticle

93 Scopus citations

Abstract

BACKGROUND-: Changes in right ventricular (RV) morphology are associated with morbidity and mortality in heart and lung disease. We examined the association of abnormal RV structure and function with the risk of heart failure or cardiovascular death in a population-based multiethnic sample free of clinical cardiovascular disease at baseline. METHODS AND RESULTS-: The Multi-Ethnic Study of Atherosclerosis (MESA) performed cardiac magnetic resonance imaging on 5098 participants between 2000 and 2002 with follow-up for incident heart failure and cardiovascular death ("death") until January 2008. RV volumes and mass were available for 4204 participants. The study sample (n=4144) was 61.4±10.1 years old and 47.6% male. The presence of RV hypertrophy (increased RV mass) was associated with more than twice the risk of heart failure or death after adjustment for demographics, body mass index, education, C-reactive protein level, hypertension, and smoking status (hazard ratio, 2.52; 95% confidence interval, 1.55-4.10; P<0.001) and a doubling (or more) of risk with left ventricular mass at the mean value or lower (P for interaction=0.05). CONCLUSIONS-: RV hypertrophy was associated with the risk of heart failure or death in a multiethnic population free of clinical cardiovascular disease at baseline.

Original languageEnglish (US)
Pages (from-to)1681-1688
Number of pages8
JournalCirculation
Volume126
Issue number14
DOIs
StatePublished - Oct 2 2012

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Keywords

  • heart ventricles
  • hypertension, pulmonary
  • magnetic resonance imaging
  • pulmonary heart disease
  • survival

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Kawut, S. M., Barr, R. G., Lima, J. A. C., Praestgaard, A., Johnson, W. C., Chahal, H., Ogunyankin, K. O., Bristow, M. R., Kizer, J. R., Tandri, H., & Bluemke, D. A. (2012). Right ventricular structure is associated with the risk of heart failure and cardiovascular death: The multi-ethnic study of atherosclerosis (MESA)-right ventricle study. Circulation, 126(14), 1681-1688. https://doi.org/10.1161/CIRCULATIONAHA.112.095216