Riboflavin-UVA collagen cross-linking for the treatment of acanthamoeba keratitis

Choul Yong Park, Roy S. Chuck

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

In this review, recent studies regarding riboflavin-ultraviolet A (UVA) collagen cross-linking for the treatment of acanthamoeba keratitis (AK) were reviewed. English written studies about acanthamoeba, keratitis, riboflavin and collagen cross-linking were retrieved from PubMed search engine (www.ncbi.nlm.nih.gov/pubmed). Although there were significant numbers of cases reporting the effectiveness of riboflavin-UVA collagen cross-linking in AK, experimental studies (in vivo and in vitro) failed to verify amoebicidal or cysticidal effect of riboflavin-UVA collagen cross-linking. In conclusion, the efficacy of riboflavin-UVA collagen cross-linking for the treatment of AK is still debatable. It is necessary to conduct a prospective case-control study for clear guidance for clinicians.

Original languageEnglish (US)
JournalAnnals of Eye Science
Volume4
Issue number2
DOIs
StatePublished - Feb 1 2019

Keywords

  • Acanthamoeba
  • Collagen
  • Cross-linking
  • Keratitis
  • Riboflavin
  • Ultraviolet A (UVA)

ASJC Scopus subject areas

  • Ophthalmology

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