Riboflavin-UVA collagen cross-linking for the treatment of acanthamoeba keratitis

Choul Yong Park; Roy S. Chuck

doi:10.21037/aes.2019.01.06

Riboflavin-UVA collagen cross-linking for the treatment of acanthamoeba keratitis

Choul Yong Park, Roy S. Chuck

Ophthalmology & Visual Sciences

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

In this review, recent studies regarding riboflavin-ultraviolet A (UVA) collagen cross-linking for the treatment of acanthamoeba keratitis (AK) were reviewed. English written studies about acanthamoeba, keratitis, riboflavin and collagen cross-linking were retrieved from PubMed search engine (www.ncbi.nlm.nih.gov/pubmed). Although there were significant numbers of cases reporting the effectiveness of riboflavin-UVA collagen cross-linking in AK, experimental studies (in vivo and in vitro) failed to verify amoebicidal or cysticidal effect of riboflavin-UVA collagen cross-linking. In conclusion, the efficacy of riboflavin-UVA collagen cross-linking for the treatment of AK is still debatable. It is necessary to conduct a prospective case-control study for clear guidance for clinicians.

Original language	English (US)
Journal	Annals of Eye Science
Volume	4
Issue number	2
DOIs	https://doi.org/10.21037/aes.2019.01.06
State	Published - Feb 1 2019

Keywords

Acanthamoeba
Collagen
Cross-linking
Keratitis
Riboflavin
Ultraviolet A (UVA)

ASJC Scopus subject areas

Ophthalmology

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10.21037/aes.2019.01.06

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title = "Riboflavin-UVA collagen cross-linking for the treatment of acanthamoeba keratitis",

abstract = "In this review, recent studies regarding riboflavin-ultraviolet A (UVA) collagen cross-linking for the treatment of acanthamoeba keratitis (AK) were reviewed. English written studies about acanthamoeba, keratitis, riboflavin and collagen cross-linking were retrieved from PubMed search engine (www.ncbi.nlm.nih.gov/pubmed). Although there were significant numbers of cases reporting the effectiveness of riboflavin-UVA collagen cross-linking in AK, experimental studies (in vivo and in vitro) failed to verify amoebicidal or cysticidal effect of riboflavin-UVA collagen cross-linking. In conclusion, the efficacy of riboflavin-UVA collagen cross-linking for the treatment of AK is still debatable. It is necessary to conduct a prospective case-control study for clear guidance for clinicians.",

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AU - Park, Choul Yong

AU - Chuck, Roy S.

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N2 - In this review, recent studies regarding riboflavin-ultraviolet A (UVA) collagen cross-linking for the treatment of acanthamoeba keratitis (AK) were reviewed. English written studies about acanthamoeba, keratitis, riboflavin and collagen cross-linking were retrieved from PubMed search engine (www.ncbi.nlm.nih.gov/pubmed). Although there were significant numbers of cases reporting the effectiveness of riboflavin-UVA collagen cross-linking in AK, experimental studies (in vivo and in vitro) failed to verify amoebicidal or cysticidal effect of riboflavin-UVA collagen cross-linking. In conclusion, the efficacy of riboflavin-UVA collagen cross-linking for the treatment of AK is still debatable. It is necessary to conduct a prospective case-control study for clear guidance for clinicians.

AB - In this review, recent studies regarding riboflavin-ultraviolet A (UVA) collagen cross-linking for the treatment of acanthamoeba keratitis (AK) were reviewed. English written studies about acanthamoeba, keratitis, riboflavin and collagen cross-linking were retrieved from PubMed search engine (www.ncbi.nlm.nih.gov/pubmed). Although there were significant numbers of cases reporting the effectiveness of riboflavin-UVA collagen cross-linking in AK, experimental studies (in vivo and in vitro) failed to verify amoebicidal or cysticidal effect of riboflavin-UVA collagen cross-linking. In conclusion, the efficacy of riboflavin-UVA collagen cross-linking for the treatment of AK is still debatable. It is necessary to conduct a prospective case-control study for clear guidance for clinicians.

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KW - Collagen

KW - Cross-linking

KW - Keratitis

KW - Riboflavin

KW - Ultraviolet A (UVA)

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Riboflavin-UVA collagen cross-linking for the treatment of acanthamoeba keratitis

Abstract

Keywords

ASJC Scopus subject areas

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