Review of the morphological aspects of remyelination

The advent of proper preparative and experimental techniques has allowed us to investigate the central nervous system myelin both in the normal animal and during remyelination. Remyelination often follows the pattern of myelination during development but, in addition, shows certain variations such as participation of Schwann cells, and is apparently always incomplete. Observations in multiple sclerosis indicate that the abortive remyelination which occurs in the demyelinated plaque is similar to that seen in the experimental animals.