TY - JOUR
T1 - Review of Systemic Immunosuppression for Autoimmune Uveitis
AU - Castiblanco, Claudia
AU - Foster, C. Stephen
N1 - Publisher Copyright:
© 2014, The Author(s).
PY - 2014/12/4
Y1 - 2014/12/4
N2 - The purpose of this review is to comprehensively examine the various therapeutic agents available to treat autoimmune eye disease, their indications, clinical safety and recent developments. The stepladder approach is reviewed, including corticosteroid administration of various forms, classic immunomodulators, and newer biologic response modifiers. The authors present that corticosteroid monotherapy is almost never curative and carries significant side effects, while immunomodulatory therapy, when used appropriately as way to induce steroid-free remission, carries far less risk of causing long-term complications and provides greater potential of altering the immune system to induce a durable remission.
AB - The purpose of this review is to comprehensively examine the various therapeutic agents available to treat autoimmune eye disease, their indications, clinical safety and recent developments. The stepladder approach is reviewed, including corticosteroid administration of various forms, classic immunomodulators, and newer biologic response modifiers. The authors present that corticosteroid monotherapy is almost never curative and carries significant side effects, while immunomodulatory therapy, when used appropriately as way to induce steroid-free remission, carries far less risk of causing long-term complications and provides greater potential of altering the immune system to induce a durable remission.
KW - Corticosteroid
KW - Immunomodulatory therapy
KW - Inflammation
KW - Ophthalmology
KW - Uveitis
UR - http://www.scopus.com/inward/record.url?scp=84914670823&partnerID=8YFLogxK
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U2 - 10.1007/s40123-014-0023-x
DO - 10.1007/s40123-014-0023-x
M3 - Review article
AN - SCOPUS:84914670823
SN - 2193-8245
VL - 3
SP - 17
EP - 36
JO - Ophthalmology and Therapy
JF - Ophthalmology and Therapy
IS - 1-2
ER -