Reversible posterior leuko-encephalopathy in children with sickle cell disease

Zarir Khademian, Barbara Speller-Brown, Seyed Medhi Nouraie, Caterina P. Minniti

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Children with sickle cell disease(SCD) have high risk of neurologic morbidity and mortality, such as strokes, silent infarcts and TIA's. A retrospective review of magnetic resonance imaging and magnetic resonance angiography identified eight children with radiological and clinical characteristics of reversible posterior encephalopathy(RPLS). These patients had no evidence of previous cerebral infarcts or vasculopathy. Three have died during the 5-year follow up; one developed a stroke and one a conditional TCD. RPLS needs to be considered in the differential diagnosis of children with SCD that present with acute neurological changes, especially if they are already been hospitalized.

Original languageEnglish (US)
Pages (from-to)373-375
Number of pages3
JournalPediatric Blood and Cancer
Volume52
Issue number3
DOIs
StatePublished - Mar 2009
Externally publishedYes

Fingerprint

Sickle Cell Anemia
Brain Diseases
Stroke
Magnetic Resonance Angiography
Nervous System
Differential Diagnosis
Magnetic Resonance Imaging
Morbidity
Mortality

Keywords

  • Hemoglobinopathies
  • Neurology and sickle cell
  • Sickle cell disease

ASJC Scopus subject areas

  • Oncology
  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Medicine(all)

Cite this

Reversible posterior leuko-encephalopathy in children with sickle cell disease. / Khademian, Zarir; Speller-Brown, Barbara; Nouraie, Seyed Medhi; Minniti, Caterina P.

In: Pediatric Blood and Cancer, Vol. 52, No. 3, 03.2009, p. 373-375.

Research output: Contribution to journalArticle

Khademian, Zarir ; Speller-Brown, Barbara ; Nouraie, Seyed Medhi ; Minniti, Caterina P. / Reversible posterior leuko-encephalopathy in children with sickle cell disease. In: Pediatric Blood and Cancer. 2009 ; Vol. 52, No. 3. pp. 373-375.
@article{e1913610c17f4971ad90864889ef6e70,
title = "Reversible posterior leuko-encephalopathy in children with sickle cell disease",
abstract = "Children with sickle cell disease(SCD) have high risk of neurologic morbidity and mortality, such as strokes, silent infarcts and TIA's. A retrospective review of magnetic resonance imaging and magnetic resonance angiography identified eight children with radiological and clinical characteristics of reversible posterior encephalopathy(RPLS). These patients had no evidence of previous cerebral infarcts or vasculopathy. Three have died during the 5-year follow up; one developed a stroke and one a conditional TCD. RPLS needs to be considered in the differential diagnosis of children with SCD that present with acute neurological changes, especially if they are already been hospitalized.",
keywords = "Hemoglobinopathies, Neurology and sickle cell, Sickle cell disease",
author = "Zarir Khademian and Barbara Speller-Brown and Nouraie, {Seyed Medhi} and Minniti, {Caterina P.}",
year = "2009",
month = "3",
doi = "10.1002/pbc.21812",
language = "English (US)",
volume = "52",
pages = "373--375",
journal = "Pediatric Blood and Cancer",
issn = "1545-5009",
publisher = "Wiley-Liss Inc.",
number = "3",

}

TY - JOUR

T1 - Reversible posterior leuko-encephalopathy in children with sickle cell disease

AU - Khademian, Zarir

AU - Speller-Brown, Barbara

AU - Nouraie, Seyed Medhi

AU - Minniti, Caterina P.

PY - 2009/3

Y1 - 2009/3

N2 - Children with sickle cell disease(SCD) have high risk of neurologic morbidity and mortality, such as strokes, silent infarcts and TIA's. A retrospective review of magnetic resonance imaging and magnetic resonance angiography identified eight children with radiological and clinical characteristics of reversible posterior encephalopathy(RPLS). These patients had no evidence of previous cerebral infarcts or vasculopathy. Three have died during the 5-year follow up; one developed a stroke and one a conditional TCD. RPLS needs to be considered in the differential diagnosis of children with SCD that present with acute neurological changes, especially if they are already been hospitalized.

AB - Children with sickle cell disease(SCD) have high risk of neurologic morbidity and mortality, such as strokes, silent infarcts and TIA's. A retrospective review of magnetic resonance imaging and magnetic resonance angiography identified eight children with radiological and clinical characteristics of reversible posterior encephalopathy(RPLS). These patients had no evidence of previous cerebral infarcts or vasculopathy. Three have died during the 5-year follow up; one developed a stroke and one a conditional TCD. RPLS needs to be considered in the differential diagnosis of children with SCD that present with acute neurological changes, especially if they are already been hospitalized.

KW - Hemoglobinopathies

KW - Neurology and sickle cell

KW - Sickle cell disease

UR - http://www.scopus.com/inward/record.url?scp=58949088344&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58949088344&partnerID=8YFLogxK

U2 - 10.1002/pbc.21812

DO - 10.1002/pbc.21812

M3 - Article

C2 - 19003906

AN - SCOPUS:58949088344

VL - 52

SP - 373

EP - 375

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

SN - 1545-5009

IS - 3

ER -