Reversibility of deficient sleep entrained growth hormone secretion in a boy with achondroplasia and obstructive sleep apnea

S. J. Goldstein, R. H K Wu, M. J. Thorpy, R. J. Shprintzen, R. E. Marion, P. Saenger

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Obstructive sleep apnea may lead to disordered sleep architecture and impair the physiologic slow wave sleep related growth hormone release. Obstructive sleep apnea occurs with craniofacial syndromes and in children with airway narrowing, pharyngeal hypoplasia, tonsillar adenoidal hypertrophy, micrognathia and achondroplasia. To examine the relationship between disordered sleep and growth hormone release we studied a 9 year old male with achondroplasia, growth failure (3 cm/year) and obstructive sleep apnea., Polysomnography data and a 20 min sampling for sleep entrained growth hormone showed before therapeutic tracheostomy numerous apneic episodes, absent slow wave sleep and abnormal low growth hormone secretion during sleep. Normalized slow wave sleep entrained growth hormone secretion after tracheostomy led to a sustained increase in growth rate. Normal growth rate (>5 cm/year) continues 2 years after tracheostomy. We conclude that obstructive sleep apnea may impair sleep related growth hormone release. Obstructive sleep apnea may be a useful model for other diseases in which growth failure and sleep disturbances are linked.

Original languageEnglish (US)
Pages (from-to)95-101
Number of pages7
JournalActa Endocrinologica
Volume116
Issue number1
StatePublished - 1987

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Achondroplasia
Obstructive Sleep Apnea
Growth Hormone
Sleep
Tracheostomy
Growth
Micrognathism
Polysomnography
Hypertrophy

ASJC Scopus subject areas

  • Endocrinology

Cite this

Reversibility of deficient sleep entrained growth hormone secretion in a boy with achondroplasia and obstructive sleep apnea. / Goldstein, S. J.; Wu, R. H K; Thorpy, M. J.; Shprintzen, R. J.; Marion, R. E.; Saenger, P.

In: Acta Endocrinologica, Vol. 116, No. 1, 1987, p. 95-101.

Research output: Contribution to journalArticle

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