Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells

Jay W. Schneider, Wei Gu, Liang Zhu, Vijak Mahdavi, Bernardo Nadal-Ginard

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329 Citations (Scopus)

Abstract

The terminal differentiation of mammalian muscle cells requires the tumor suppressor retinoblastoma protein (Rb). Unlike their wild-type counterparts, multinucleated myotubes from mouse cells deficient in Rb (Rb-/-) were induced by serum to reenter the cell cycle. Development of the myogenic phenotype in Rb-1- cells correlated with increased expression of p107, which interacted with myogenic transcription factors. Serum-induced cell cycle reentry, on the other hand, correlated with decreased p107 expression. Thus, although p107 could substitute for Rb as a cofactor for differentiation, it could not maintain the terminally differentiated state in Rb-1- myotubes.

Original languageEnglish (US)
Pages (from-to)1467-1471
Number of pages5
JournalScience
Volume264
Issue number5164
StatePublished - Jun 3 1994
Externally publishedYes

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Skeletal Muscle Fibers
Muscle Cells
Cell Cycle
Tumor Suppressor Proteins
Retinoblastoma Protein
Serum
Transcription Factors
Phenotype

ASJC Scopus subject areas

  • General

Cite this

Schneider, J. W., Gu, W., Zhu, L., Mahdavi, V., & Nadal-Ginard, B. (1994). Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells. Science, 264(5164), 1467-1471.

Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells. / Schneider, Jay W.; Gu, Wei; Zhu, Liang; Mahdavi, Vijak; Nadal-Ginard, Bernardo.

In: Science, Vol. 264, No. 5164, 03.06.1994, p. 1467-1471.

Research output: Contribution to journalArticle

Schneider, JW, Gu, W, Zhu, L, Mahdavi, V & Nadal-Ginard, B 1994, 'Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells', Science, vol. 264, no. 5164, pp. 1467-1471.
Schneider JW, Gu W, Zhu L, Mahdavi V, Nadal-Ginard B. Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells. Science. 1994 Jun 3;264(5164):1467-1471.
Schneider, Jay W. ; Gu, Wei ; Zhu, Liang ; Mahdavi, Vijak ; Nadal-Ginard, Bernardo. / Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells. In: Science. 1994 ; Vol. 264, No. 5164. pp. 1467-1471.
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