Abstract
The significance of HIV associated paraproteins and their risk of progression to hematological malignancies remains unclear. We compared the development of hematological malignancies among HIV+ (n = 266) and HIV- (n = 537) patients with monoclonal gammopathies. HIV+ and HIV- patients with a positive serum protein electrophoresis test (SPEP) were studied. HIV+ SPEP+ were more likely to have faint and oligoclonal paraproteins (F-SPEP) and less likely to have discrete bands (D-SPEP) compared to HIV- SPEP+. The incidence of hematological malignancies was significantly lower in the HIV+ compared to the HIV- (6.4% vs 15.4%, p<0.0002). Upon subgroup analysis, the lower incidence of hematological malignancies was noted for HIV+ patients with F-SPEP but not for those with D-SPEP.
Original language | English (US) |
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Pages (from-to) | 64-68 |
Number of pages | 5 |
Journal | Hematological Oncology |
Volume | 35 |
Issue number | 1 |
DOIs | |
State | Published - Mar 1 2017 |
Keywords
- HIV
- Hematological malignancy
- Monoclonal proteins
- Oligoclonal proteins
- Paraproteins
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research