Retrospective study of the prevalence and progression of monoclonal gammopathy in HIV positive versus HIV negative patients

Erin Jou, Oleg Gligich, Alvita C Y Chan, Diwakar Mohan, Uriel R. Felsen, Sabarish Ayyappan, Henny H. Billett, Edwin P. Hui, Anthony T. Chan, Radha Raghupathy

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The significance of HIV associated paraproteins and their risk of progression to hematological malignancies remains unclear. We compared the development of hematological malignancies among HIV+ (n=266) and HIV- (n=537) patients with monoclonal gammopathies. HIV+ and HIV- patients with a positive serum protein electrophoresis test (SPEP) were studied. HIV+ SPEP+ were more likely to have faint and oligoclonal paraproteins (F-SPEP) and less likely to have discrete bands (D-SPEP) compared to HIV- SPEP+. The incidence of hematological malignancies was significantly lower in the HIV+ compared to the HIV- (6.4% vs 15.4%, p<0.0002). Upon subgroup analysis, the lower incidence of hematological malignancies was noted for HIV+ patients with F-SPEP but not for those with D-SPEP.

Original languageEnglish (US)
JournalHematological Oncology
DOIs
StateAccepted/In press - 2015

Fingerprint

Paraproteinemias
Retrospective Studies
Electrophoresis
Blood Proteins
HIV
Hematologic Neoplasms
Paraproteins
Human Immunodeficiency Virus Proteins
Incidence

Keywords

  • Hematological malignancy
  • HIV
  • Monoclonal proteins
  • Oligoclonal proteins
  • Paraproteins

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Retrospective study of the prevalence and progression of monoclonal gammopathy in HIV positive versus HIV negative patients. / Jou, Erin; Gligich, Oleg; Chan, Alvita C Y; Mohan, Diwakar; Felsen, Uriel R.; Ayyappan, Sabarish; Billett, Henny H.; Hui, Edwin P.; Chan, Anthony T.; Raghupathy, Radha.

In: Hematological Oncology, 2015.

Research output: Contribution to journalArticle

Jou, Erin ; Gligich, Oleg ; Chan, Alvita C Y ; Mohan, Diwakar ; Felsen, Uriel R. ; Ayyappan, Sabarish ; Billett, Henny H. ; Hui, Edwin P. ; Chan, Anthony T. ; Raghupathy, Radha. / Retrospective study of the prevalence and progression of monoclonal gammopathy in HIV positive versus HIV negative patients. In: Hematological Oncology. 2015.
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