Retrospective study of the prevalence and progression of monoclonal gammopathy in HIV positive versus HIV negative patients

Erin Jou, Oleg Gligich, Alvita C.Y. Chan, Diwakar Mohan, Uriel R. Felsen, Sabarish Ayyappan, Henny H. Billett, Edwin P. Hui, Anthony T. Chan, Radha Raghupathy

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The significance of HIV associated paraproteins and their risk of progression to hematological malignancies remains unclear. We compared the development of hematological malignancies among HIV+ (n = 266) and HIV- (n = 537) patients with monoclonal gammopathies. HIV+ and HIV- patients with a positive serum protein electrophoresis test (SPEP) were studied. HIV+ SPEP+ were more likely to have faint and oligoclonal paraproteins (F-SPEP) and less likely to have discrete bands (D-SPEP) compared to HIV- SPEP+. The incidence of hematological malignancies was significantly lower in the HIV+ compared to the HIV- (6.4% vs 15.4%, p<0.0002). Upon subgroup analysis, the lower incidence of hematological malignancies was noted for HIV+ patients with F-SPEP but not for those with D-SPEP.

Original languageEnglish (US)
Pages (from-to)64-68
Number of pages5
JournalHematological Oncology
Volume35
Issue number1
DOIs
StatePublished - Mar 1 2017

Keywords

  • HIV
  • Hematological malignancy
  • Monoclonal proteins
  • Oligoclonal proteins
  • Paraproteins

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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