Retraction Notice to

Nested Inversion Polymorphisms Predispose Chromosome 22q11.2 to Meiotic Rearrangements (The American Journal of Human Genetics (2017) 101(4) (616–622), (S0002929717303695) (10.1016/j.ajhg.2017.09.002))

International 22q11.2 Brain and Behavior Consortium

Research output: Contribution to journalComment/debate

Abstract

(The American Journal of Human Genetics 101, 616–622; October 5, 2017) This article has been retracted at the request of the authors. In this article, we claimed the presence of nested inversion polymorphisms, spanning the LCR22-B/D or LCR22-C/D locus. We detected an increased frequency of inversions in the chromosomes of the parental genome in which the 22qll.2 rearrangement occurred. Since this publication, we have continued working on an improved map of the 22qll Iocus. During these efforts, we were unable to confirm the presence of the inversion polymorphism. We proved the polymorphism to be absent and the original data to be biased. Absence of a double-blinded control left complex observations open to interpretation and hampered objective analysis. With this crucial flaw uncovered, we no longer support these data and are retracting the article. We apologize to the scientific community, the readers of AJHG, and the families who were involved in this research.

Original languageEnglish (US)
Number of pages1
JournalAmerican Journal of Human Genetics
Volume103
Issue number3
DOIs
StatePublished - Sep 6 2018

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Medical Genetics
Chromosomes
Genome
Research

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

@article{32a83b06cabd4f34a32047005a191941,
title = "Retraction Notice to: Nested Inversion Polymorphisms Predispose Chromosome 22q11.2 to Meiotic Rearrangements (The American Journal of Human Genetics (2017) 101(4) (616–622), (S0002929717303695) (10.1016/j.ajhg.2017.09.002))",
abstract = "(The American Journal of Human Genetics 101, 616–622; October 5, 2017) This article has been retracted at the request of the authors. In this article, we claimed the presence of nested inversion polymorphisms, spanning the LCR22-B/D or LCR22-C/D locus. We detected an increased frequency of inversions in the chromosomes of the parental genome in which the 22qll.2 rearrangement occurred. Since this publication, we have continued working on an improved map of the 22qll Iocus. During these efforts, we were unable to confirm the presence of the inversion polymorphism. We proved the polymorphism to be absent and the original data to be biased. Absence of a double-blinded control left complex observations open to interpretation and hampered objective analysis. With this crucial flaw uncovered, we no longer support these data and are retracting the article. We apologize to the scientific community, the readers of AJHG, and the families who were involved in this research.",
author = "{International 22q11.2 Brain and Behavior Consortium} and Wolfram Demaerel and Hestand, {Matthew S.} and Elfi Vergaelen and Ann Swillen and Marcos L{\'o}pez-S{\'a}nchez and P{\'e}rez-Jurado, {Luis A.} and McDonald-McGinn, {Donna M.} and Elaine Zackai and Emanuel, {Beverly S.} and Morrow, {Bernice E.} and Jeroen Breckpot and Koenraad Devriendt and Vermeesch, {Joris R.} and Kevin Antshel and Celso Arango and Marco Armando and Anne Bassett and Carrie Bearden and Erik Boot and Marta Bravo-Sanchez and Elemi Breetvelt and Tiffany Busa and Nancy Butcher and Linda Campbell and Miri Carmel and Eva Chow and Crowley, {T. Blaine} and Joseph Cubells and David Cutler and Wolfram Demaerel and Digilio, {Maria Cristina} and Sasja Duijff and Stephan Eliez and Beverly Emanuel and Michael Epstein and Rens Evers and {Fernandez Garcia-Moya}, Luis and Ania Fiksinski and David Fraguas and Wanda Fremont and Rosemarie Fritsch and Sixto Garcia-Minaur and Aaron Golden and Doron Gothelf and Tingwei Guo and Ruben Gur and Raquel Gur and Damian Heine-Suner and Matthew Hestand and Zhengdong Zhang",
year = "2018",
month = "9",
day = "6",
doi = "10.1016/j.ajhg.2018.08.011",
language = "English (US)",
volume = "103",
journal = "American Journal of Human Genetics",
issn = "0002-9297",
publisher = "Cell Press",
number = "3",

}

TY - JOUR

T1 - Retraction Notice to

T2 - Nested Inversion Polymorphisms Predispose Chromosome 22q11.2 to Meiotic Rearrangements (The American Journal of Human Genetics (2017) 101(4) (616–622), (S0002929717303695) (10.1016/j.ajhg.2017.09.002))

AU - International 22q11.2 Brain and Behavior Consortium

AU - Demaerel, Wolfram

AU - Hestand, Matthew S.

AU - Vergaelen, Elfi

AU - Swillen, Ann

AU - López-Sánchez, Marcos

AU - Pérez-Jurado, Luis A.

AU - McDonald-McGinn, Donna M.

AU - Zackai, Elaine

AU - Emanuel, Beverly S.

AU - Morrow, Bernice E.

AU - Breckpot, Jeroen

AU - Devriendt, Koenraad

AU - Vermeesch, Joris R.

AU - Antshel, Kevin

AU - Arango, Celso

AU - Armando, Marco

AU - Bassett, Anne

AU - Bearden, Carrie

AU - Boot, Erik

AU - Bravo-Sanchez, Marta

AU - Breetvelt, Elemi

AU - Busa, Tiffany

AU - Butcher, Nancy

AU - Campbell, Linda

AU - Carmel, Miri

AU - Chow, Eva

AU - Crowley, T. Blaine

AU - Cubells, Joseph

AU - Cutler, David

AU - Demaerel, Wolfram

AU - Digilio, Maria Cristina

AU - Duijff, Sasja

AU - Eliez, Stephan

AU - Emanuel, Beverly

AU - Epstein, Michael

AU - Evers, Rens

AU - Fernandez Garcia-Moya, Luis

AU - Fiksinski, Ania

AU - Fraguas, David

AU - Fremont, Wanda

AU - Fritsch, Rosemarie

AU - Garcia-Minaur, Sixto

AU - Golden, Aaron

AU - Gothelf, Doron

AU - Guo, Tingwei

AU - Gur, Ruben

AU - Gur, Raquel

AU - Heine-Suner, Damian

AU - Hestand, Matthew

AU - Zhang, Zhengdong

PY - 2018/9/6

Y1 - 2018/9/6

N2 - (The American Journal of Human Genetics 101, 616–622; October 5, 2017) This article has been retracted at the request of the authors. In this article, we claimed the presence of nested inversion polymorphisms, spanning the LCR22-B/D or LCR22-C/D locus. We detected an increased frequency of inversions in the chromosomes of the parental genome in which the 22qll.2 rearrangement occurred. Since this publication, we have continued working on an improved map of the 22qll Iocus. During these efforts, we were unable to confirm the presence of the inversion polymorphism. We proved the polymorphism to be absent and the original data to be biased. Absence of a double-blinded control left complex observations open to interpretation and hampered objective analysis. With this crucial flaw uncovered, we no longer support these data and are retracting the article. We apologize to the scientific community, the readers of AJHG, and the families who were involved in this research.

AB - (The American Journal of Human Genetics 101, 616–622; October 5, 2017) This article has been retracted at the request of the authors. In this article, we claimed the presence of nested inversion polymorphisms, spanning the LCR22-B/D or LCR22-C/D locus. We detected an increased frequency of inversions in the chromosomes of the parental genome in which the 22qll.2 rearrangement occurred. Since this publication, we have continued working on an improved map of the 22qll Iocus. During these efforts, we were unable to confirm the presence of the inversion polymorphism. We proved the polymorphism to be absent and the original data to be biased. Absence of a double-blinded control left complex observations open to interpretation and hampered objective analysis. With this crucial flaw uncovered, we no longer support these data and are retracting the article. We apologize to the scientific community, the readers of AJHG, and the families who were involved in this research.

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UR - http://www.scopus.com/inward/citedby.url?scp=85053143631&partnerID=8YFLogxK

U2 - 10.1016/j.ajhg.2018.08.011

DO - 10.1016/j.ajhg.2018.08.011

M3 - Comment/debate

VL - 103

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

SN - 0002-9297

IS - 3

ER -