TY - JOUR
T1 - Retinoids and the prevention of cervical dysplasias
AU - Romney, S. L.
AU - Palan, P. R.
AU - Duttagupta, C.
AU - Wassertheil-Smoller, S.
AU - Wylie, J.
AU - Miller, G.
AU - Slagle, N. S.
AU - Lucido, D.
PY - 1981/1/1
Y1 - 1981/1/1
N2 - Women with abnormal cytology were matched with normal control subjects for age, parity, ethnicity, and socioeconomic class and participated in a blind case-control study focused on the role of nutrition in cervical dysplasia. Sucrose gradient ultracentrifugation studies for determination of the presence and concentration of the binding proteins for retinol and retinoic acid were performed on colposcopic biopsy tissue specimens. The nutritional survey revealed statistically significant differences for vitamins A and C and beta carotene. Retinol binding protein was absent or minimally detectable and inversely related to the severity of the dysplasia. It is proposed that a double-blind clinical trial be conducted to evaluate whether retinoids may pharmacologically inhibit, arrest, or reverse cervical dysplasia.
AB - Women with abnormal cytology were matched with normal control subjects for age, parity, ethnicity, and socioeconomic class and participated in a blind case-control study focused on the role of nutrition in cervical dysplasia. Sucrose gradient ultracentrifugation studies for determination of the presence and concentration of the binding proteins for retinol and retinoic acid were performed on colposcopic biopsy tissue specimens. The nutritional survey revealed statistically significant differences for vitamins A and C and beta carotene. Retinol binding protein was absent or minimally detectable and inversely related to the severity of the dysplasia. It is proposed that a double-blind clinical trial be conducted to evaluate whether retinoids may pharmacologically inhibit, arrest, or reverse cervical dysplasia.
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U2 - 10.1016/S0002-9378(16)32680-1
DO - 10.1016/S0002-9378(16)32680-1
M3 - Article
C2 - 7198387
AN - SCOPUS:0019857792
SN - 0946-672X
VL - 141
SP - 890
EP - 894
JO - Journal of Trace Elements in Medicine and Biology
JF - Journal of Trace Elements in Medicine and Biology
IS - 8
ER -