Retinoid signaling in inner ear development

A "Goldilocks" phenomenon

Dorothy A. Frenz, Wei Liu, Ales Cvekl, Qing Xie, Lesley Wassef, Loredana Quadro, Karen Niederreither, Mark Maconochie, Alan Shanske

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Retinoic acid (RA) is a biologically active derivative of vitamin A that is indispensable for inner ear development. The normal function of RA is achieved only at optimal homeostatic concentrations, with an excess or deficiency in RA leading to inner ear dysmorphogenesis. We present an overview of the role of RA in the developing mammalian inner ear, discussing both how and when RA may act to critically control a program of inner ear development. Molecular mechanisms of otic teratogenicity involving two members of the fibroblast growth factor family, FGF3 and FGF10, and their downstream targets, Dlx5 and Dlx6, are examined under conditions of both RA excess and deficiency. We term the effect of too little or too much RA on FGF/Dlx signaling a Goldilocks phenomenon. We demonstrate that in each case (RA excess, RA deficiency), RA can directly affect FGF3/FGF10 signaling within the otic epithelium, leading to downregulated expression of these essential signaling molecules, which in turn, leads to diminution in Dlx5/Dlx6 expression. Non-cell autonomous affects of the otic epithelium subsequently occur, altering transforming growth factor-beta (TGFβ) expression in the neighboring periotic mesenchyme and serving as a putative explanation for RA-mediated otic capsule defects. We conclude that RA coordinates inner ear morphogenesis by controlling an FGF/Dlx signaling cascade, whose perturbation by deviations in local retinoid concentrations can lead to inner ear dysmorphogenesis.

Original languageEnglish (US)
Pages (from-to)2947-2961
Number of pages15
JournalAmerican Journal of Medical Genetics, Part A
Volume152 A
Issue number12
DOIs
StatePublished - Dec 2010

Fingerprint

Retinoids
Inner Ear
Tretinoin
Ear
Epithelium
Fibroblast Growth Factors
Mesoderm
Vitamin A
Morphogenesis
Transforming Growth Factor beta
Capsules
Down-Regulation

Keywords

  • Dlx
  • Dysmorphogenesis
  • Fibroblast growth factor
  • Inner ear
  • Retinoic acid

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Retinoid signaling in inner ear development : A "Goldilocks" phenomenon. / Frenz, Dorothy A.; Liu, Wei; Cvekl, Ales; Xie, Qing; Wassef, Lesley; Quadro, Loredana; Niederreither, Karen; Maconochie, Mark; Shanske, Alan.

In: American Journal of Medical Genetics, Part A, Vol. 152 A, No. 12, 12.2010, p. 2947-2961.

Research output: Contribution to journalArticle

Frenz, DA, Liu, W, Cvekl, A, Xie, Q, Wassef, L, Quadro, L, Niederreither, K, Maconochie, M & Shanske, A 2010, 'Retinoid signaling in inner ear development: A "Goldilocks" phenomenon', American Journal of Medical Genetics, Part A, vol. 152 A, no. 12, pp. 2947-2961. https://doi.org/10.1002/ajmg.a.33670
Frenz, Dorothy A. ; Liu, Wei ; Cvekl, Ales ; Xie, Qing ; Wassef, Lesley ; Quadro, Loredana ; Niederreither, Karen ; Maconochie, Mark ; Shanske, Alan. / Retinoid signaling in inner ear development : A "Goldilocks" phenomenon. In: American Journal of Medical Genetics, Part A. 2010 ; Vol. 152 A, No. 12. pp. 2947-2961.
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