Retinal ischemia leads to apoptosis which is ameliorated by aurintricarboxylic acid

Daniel M. Rosenbaum, Pearl S. Rosenbaum, Anita Gupta, Mark D. Michaelson, David H. Hall, John A. Kessler

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Transient retinal ischemia results in a delayed cell death of the inner retinal layers. This study demonstrates that this ischemic cell death occurs, at least in part, through apoptosis. The general endonuclease inhibitor, aurintricarboxylic acid, protected rat retinal cells from ischemic cell damage when administered before the onset of ischemia and, more importantly, when administered 6 hr after the insult. Thus, the demonstration that transient retinal ischemia results in cell damage as a result of apoptosis opens new therapeutic strategies aimed at lessening retinal damage as a result of this process.

Original languageEnglish (US)
Pages (from-to)3445-3451
Number of pages7
JournalVision Research
Volume37
Issue number24
DOIs
StatePublished - Dec 1997

Fingerprint

Aurintricarboxylic Acid
Ischemia
Apoptosis
Cell Death
Endonucleases
Therapeutics

Keywords

  • Apoptosis
  • Aurintricarboxylic acid
  • Ischemia
  • Retina

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

Rosenbaum, D. M., Rosenbaum, P. S., Gupta, A., Michaelson, M. D., Hall, D. H., & Kessler, J. A. (1997). Retinal ischemia leads to apoptosis which is ameliorated by aurintricarboxylic acid. Vision Research, 37(24), 3445-3451. https://doi.org/10.1016/S0042-6989(96)00328-8

Retinal ischemia leads to apoptosis which is ameliorated by aurintricarboxylic acid. / Rosenbaum, Daniel M.; Rosenbaum, Pearl S.; Gupta, Anita; Michaelson, Mark D.; Hall, David H.; Kessler, John A.

In: Vision Research, Vol. 37, No. 24, 12.1997, p. 3445-3451.

Research output: Contribution to journalArticle

Rosenbaum, DM, Rosenbaum, PS, Gupta, A, Michaelson, MD, Hall, DH & Kessler, JA 1997, 'Retinal ischemia leads to apoptosis which is ameliorated by aurintricarboxylic acid', Vision Research, vol. 37, no. 24, pp. 3445-3451. https://doi.org/10.1016/S0042-6989(96)00328-8
Rosenbaum, Daniel M. ; Rosenbaum, Pearl S. ; Gupta, Anita ; Michaelson, Mark D. ; Hall, David H. ; Kessler, John A. / Retinal ischemia leads to apoptosis which is ameliorated by aurintricarboxylic acid. In: Vision Research. 1997 ; Vol. 37, No. 24. pp. 3445-3451.
@article{babe32ba6d6445b882c5e811c5ef4556,
title = "Retinal ischemia leads to apoptosis which is ameliorated by aurintricarboxylic acid",
abstract = "Transient retinal ischemia results in a delayed cell death of the inner retinal layers. This study demonstrates that this ischemic cell death occurs, at least in part, through apoptosis. The general endonuclease inhibitor, aurintricarboxylic acid, protected rat retinal cells from ischemic cell damage when administered before the onset of ischemia and, more importantly, when administered 6 hr after the insult. Thus, the demonstration that transient retinal ischemia results in cell damage as a result of apoptosis opens new therapeutic strategies aimed at lessening retinal damage as a result of this process.",
keywords = "Apoptosis, Aurintricarboxylic acid, Ischemia, Retina",
author = "Rosenbaum, {Daniel M.} and Rosenbaum, {Pearl S.} and Anita Gupta and Michaelson, {Mark D.} and Hall, {David H.} and Kessler, {John A.}",
year = "1997",
month = "12",
doi = "10.1016/S0042-6989(96)00328-8",
language = "English (US)",
volume = "37",
pages = "3445--3451",
journal = "Vision Research",
issn = "0042-6989",
publisher = "Elsevier Limited",
number = "24",

}

TY - JOUR

T1 - Retinal ischemia leads to apoptosis which is ameliorated by aurintricarboxylic acid

AU - Rosenbaum, Daniel M.

AU - Rosenbaum, Pearl S.

AU - Gupta, Anita

AU - Michaelson, Mark D.

AU - Hall, David H.

AU - Kessler, John A.

PY - 1997/12

Y1 - 1997/12

N2 - Transient retinal ischemia results in a delayed cell death of the inner retinal layers. This study demonstrates that this ischemic cell death occurs, at least in part, through apoptosis. The general endonuclease inhibitor, aurintricarboxylic acid, protected rat retinal cells from ischemic cell damage when administered before the onset of ischemia and, more importantly, when administered 6 hr after the insult. Thus, the demonstration that transient retinal ischemia results in cell damage as a result of apoptosis opens new therapeutic strategies aimed at lessening retinal damage as a result of this process.

AB - Transient retinal ischemia results in a delayed cell death of the inner retinal layers. This study demonstrates that this ischemic cell death occurs, at least in part, through apoptosis. The general endonuclease inhibitor, aurintricarboxylic acid, protected rat retinal cells from ischemic cell damage when administered before the onset of ischemia and, more importantly, when administered 6 hr after the insult. Thus, the demonstration that transient retinal ischemia results in cell damage as a result of apoptosis opens new therapeutic strategies aimed at lessening retinal damage as a result of this process.

KW - Apoptosis

KW - Aurintricarboxylic acid

KW - Ischemia

KW - Retina

UR - http://www.scopus.com/inward/record.url?scp=0030838334&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030838334&partnerID=8YFLogxK

U2 - 10.1016/S0042-6989(96)00328-8

DO - 10.1016/S0042-6989(96)00328-8

M3 - Article

VL - 37

SP - 3445

EP - 3451

JO - Vision Research

JF - Vision Research

SN - 0042-6989

IS - 24

ER -