Retinal determination genes function along with cell-cell signals to regulate Drosophila eye development: Examples of multi-layered regulation by master regulators

Nicholas E. Baker, Lucy C. Firth

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

It is thought that retinal determination (RD) gene products define the response made to cell-cell signals in the field of eye development by binding to enhancers of genes that are also regulated by cell-cell signaling pathways. In Drosophila, RD genes, including eyeless, teashirt, eyes absent, dachsous, and sine oculis, are required for normal eye development and can induce ectopic eyes when mis-expressed. Characterization of the enhancers responsible for eye expression of the hedgehog, shaven, and atonal genes, as well as the dynamics of RD gene expression themselves, now suggest a multilayered network whereby transcriptional regulation by either RD genes or cell-cell signaling pathways can sometimes be indirect and mediated by other transcription factor intermediates. In this updated view of the interaction between extracellular information and cell intrinsic programs during development, regulation of individual genes might sometimes be several steps removed from either the RD genes or the cell-cell signaling pathways that nevertheless govern their expression.

Original languageEnglish (US)
Pages (from-to)538-546
Number of pages9
JournalBioEssays
Volume33
Issue number7
DOIs
StatePublished - Jul 2011

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Drosophila
Genes
Cell signaling
Gene expression
Hedgehogs
Gene Regulatory Networks
Transcription Factors
Gene Expression

Keywords

  • Cell-cell signal
  • Drosophila eye
  • Eyeless
  • Positional information
  • Retinal determination gene

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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