Abstract
Retinal determination genes are sufficient to specify eyes in ectopic locations, raising the question of how these master regulatory genes define an eye developmental field. Genetic mosaic studies establish that expression of the retinal determination genes eyeless, teashirt, homothorax, eyes absent, sine oculis, and dachshund are each regulated by combinations of Dpp, Hh, N, Wg, and Ras signals in Drosophila. Dpp and Hh control eyeless, teashirt, sine oculis, and dachshund expression, Dpp and Ras control homothorax, and all the signaling pathways affect eyes absent expression. These results suggest that eye-specific development uses retinal determination gene expression to relay positional information to eye target genes, because the distinct, overlapping patterns of retinal determination gene expression reflect the activities of the extracellular signaling pathways.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 366-375 |
| Number of pages | 10 |
| Journal | Developmental Biology |
| Volume | 327 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 15 2009 |
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Keywords
- Drosophila eye
- Master regulatory gene
- Positional information
- Retinal determination
ASJC Scopus subject areas
- Developmental Biology
- Cell Biology
- Molecular Biology
Cite this
Retinal determination genes as targets and possible effectors of extracellular signals. / Firth, Lucy C.; Baker, Nicholas E.
In: Developmental Biology, Vol. 327, No. 2, 15.03.2009, p. 366-375.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Retinal determination genes as targets and possible effectors of extracellular signals
AU - Firth, Lucy C.
AU - Baker, Nicholas E.
PY - 2009/3/15
Y1 - 2009/3/15
N2 - Retinal determination genes are sufficient to specify eyes in ectopic locations, raising the question of how these master regulatory genes define an eye developmental field. Genetic mosaic studies establish that expression of the retinal determination genes eyeless, teashirt, homothorax, eyes absent, sine oculis, and dachshund are each regulated by combinations of Dpp, Hh, N, Wg, and Ras signals in Drosophila. Dpp and Hh control eyeless, teashirt, sine oculis, and dachshund expression, Dpp and Ras control homothorax, and all the signaling pathways affect eyes absent expression. These results suggest that eye-specific development uses retinal determination gene expression to relay positional information to eye target genes, because the distinct, overlapping patterns of retinal determination gene expression reflect the activities of the extracellular signaling pathways.
AB - Retinal determination genes are sufficient to specify eyes in ectopic locations, raising the question of how these master regulatory genes define an eye developmental field. Genetic mosaic studies establish that expression of the retinal determination genes eyeless, teashirt, homothorax, eyes absent, sine oculis, and dachshund are each regulated by combinations of Dpp, Hh, N, Wg, and Ras signals in Drosophila. Dpp and Hh control eyeless, teashirt, sine oculis, and dachshund expression, Dpp and Ras control homothorax, and all the signaling pathways affect eyes absent expression. These results suggest that eye-specific development uses retinal determination gene expression to relay positional information to eye target genes, because the distinct, overlapping patterns of retinal determination gene expression reflect the activities of the extracellular signaling pathways.
KW - Drosophila eye
KW - Master regulatory gene
KW - Positional information
KW - Retinal determination
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UR - http://www.scopus.com/inward/citedby.url?scp=60549115017&partnerID=8YFLogxK
U2 - 10.1016/j.ydbio.2008.12.021
DO - 10.1016/j.ydbio.2008.12.021
M3 - Article
C2 - 19135045
AN - SCOPUS:60549115017
VL - 327
SP - 366
EP - 375
JO - Developmental Biology
JF - Developmental Biology
SN - 0012-1606
IS - 2
ER -