TY - JOUR
T1 - Rethinking T cell immunity in oropharyngeal candidiasis
AU - Pirofski, Liise Anne
AU - Casadevall, Arturo
PY - 2009/2/16
Y1 - 2009/2/16
N2 - The disproportionate increase in oropharyngeal candidiasis (OPC) compared with systemic and vaginal candidiasis in female patients with AIDS has been a paradox for almost three decades. New data now show that severe OPC develops in Th17-deficient mice, but not Th1-deficient mice, implicating Th17-induced effector molecules in resistance to oral disease. These findings clarify and extend our current thinking about how CD4 T cell deficiency influences susceptibility to OPC.
AB - The disproportionate increase in oropharyngeal candidiasis (OPC) compared with systemic and vaginal candidiasis in female patients with AIDS has been a paradox for almost three decades. New data now show that severe OPC develops in Th17-deficient mice, but not Th1-deficient mice, implicating Th17-induced effector molecules in resistance to oral disease. These findings clarify and extend our current thinking about how CD4 T cell deficiency influences susceptibility to OPC.
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U2 - 10.1084/jem.20090093
DO - 10.1084/jem.20090093
M3 - Comment/debate
C2 - 19204107
AN - SCOPUS:63049092272
SN - 0022-1007
VL - 206
SP - 269
EP - 273
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 2
ER -