Rethinking Subthreshold Effects in Regulatory Chemical Risk Assessments

Evgenios Agathokleous; Damià Barceló; Michael Aschner; Ricardo Antunes Azevedo; Prosun Bhattacharya; David Costantini; G. Christopher Cutler; Alessandra De Marco; Anca Oana Docea; José G. Dórea; Stephen O. Duke; Thomas Efferth; Despo Fatta-Kassinos; Vasileios Fotopoulos; Antonio Ginebreda; Raul Narciso C. Guedes; A. Wallace Hayes; Ivo Iavicoli; Olga Ioanna Kalantzi; Takayoshi Koike; Demetrios Kouretas; Manish Kumar; José E. Manautou; Michael N. Moore; Elena Paoletti; Josep Peñuelas; Yolanda Picó; Russel J. Reiter; Ramin Rezaee; Jörg Rinklebe; Teresa Rocha-Santos; Pierre Sicard; Christian Sonne; Christopher Teaf; Aristidis Tsatsakis; Alexander I. Vardavas; Wenjie Wang; Eddy Y. Zeng; Edward J. Calabrese

doi:10.1021/acs.est.2c02896

Rethinking Subthreshold Effects in Regulatory Chemical Risk Assessments

Evgenios Agathokleous, Damià Barceló, Michael Aschner, Ricardo Antunes Azevedo, Prosun Bhattacharya, David Costantini, G. Christopher Cutler, Alessandra De Marco, Anca Oana Docea, José G. Dórea, Stephen O. Duke, Thomas Efferth, Despo Fatta-Kassinos, Vasileios Fotopoulos, Antonio Ginebreda, Raul Narciso C. Guedes, A. Wallace Hayes, Ivo Iavicoli, Olga Ioanna Kalantzi, Takayoshi KoikeDemetrios Kouretas, Manish Kumar, José E. Manautou, Michael N. Moore, Elena Paoletti, Josep Peñuelas, Yolanda Picó, Russel J. Reiter, Ramin Rezaee, Jörg Rinklebe, Teresa Rocha-Santos, Pierre Sicard, Christian Sonne, Christopher Teaf, Aristidis Tsatsakis, Alexander I. Vardavas, Wenjie Wang, Eddy Y. Zeng, Edward J. Calabrese

Molecular Pharmacology

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

Original language	English (US)
Pages (from-to)	11095-11099
Number of pages	5
Journal	Environmental Science and Technology
Volume	56
Issue number	16
DOIs	https://doi.org/10.1021/acs.est.2c02896
State	Published - Aug 16 2022

Keywords

Chemical Risk Assessments
cancer
hormesis

ASJC Scopus subject areas

General Chemistry
Environmental Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acs.est.2c02896

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Agathokleous, E., Barceló, D., Aschner, M., Azevedo, R. A., Bhattacharya, P., Costantini, D., Cutler, G. C., De Marco, A., Docea, A. O., Dórea, J. G., Duke, S. O., Efferth, T., Fatta-Kassinos, D., Fotopoulos, V., Ginebreda, A., Guedes, R. N. C., Hayes, A. W., Iavicoli, I., Kalantzi, O. I., ... Calabrese, E. J. (2022). Rethinking Subthreshold Effects in Regulatory Chemical Risk Assessments. Environmental Science and Technology, 56(16), 11095-11099. https://doi.org/10.1021/acs.est.2c02896

Agathokleous, E, Barceló, D, Aschner, M, Azevedo, RA, Bhattacharya, P, Costantini, D, Cutler, GC, De Marco, A, Docea, AO, Dórea, JG, Duke, SO, Efferth, T, Fatta-Kassinos, D, Fotopoulos, V, Ginebreda, A, Guedes, RNC, Hayes, AW, Iavicoli, I, Kalantzi, OI, Koike, T, Kouretas, D, Kumar, M, Manautou, JE, Moore, MN, Paoletti, E, Peñuelas, J, Picó, Y, Reiter, RJ, Rezaee, R, Rinklebe, J, Rocha-Santos, T, Sicard, P, Sonne, C, Teaf, C, Tsatsakis, A, Vardavas, AI, Wang, W, Zeng, EY & Calabrese, EJ 2022, 'Rethinking Subthreshold Effects in Regulatory Chemical Risk Assessments', Environmental Science and Technology, vol. 56, no. 16, pp. 11095-11099. https://doi.org/10.1021/acs.est.2c02896

@article{b9dcbb1a22c94d25a98dfd796f9f4e53,

title = "Rethinking Subthreshold Effects in Regulatory Chemical Risk Assessments",

keywords = "Chemical Risk Assessments, cancer, hormesis",

author = "Evgenios Agathokleous and Dami{\`a} Barcel{\'o} and Michael Aschner and Azevedo, {Ricardo Antunes} and Prosun Bhattacharya and David Costantini and Cutler, {G. Christopher} and {De Marco}, Alessandra and Docea, {Anca Oana} and D{\'o}rea, {Jos{\'e} G.} and Duke, {Stephen O.} and Thomas Efferth and Despo Fatta-Kassinos and Vasileios Fotopoulos and Antonio Ginebreda and Guedes, {Raul Narciso C.} and Hayes, {A. Wallace} and Ivo Iavicoli and Kalantzi, {Olga Ioanna} and Takayoshi Koike and Demetrios Kouretas and Manish Kumar and Manautou, {Jos{\'e} E.} and Moore, {Michael N.} and Elena Paoletti and Josep Pe{\~n}uelas and Yolanda Pic{\'o} and Reiter, {Russel J.} and Ramin Rezaee and J{\"o}rg Rinklebe and Teresa Rocha-Santos and Pierre Sicard and Christian Sonne and Christopher Teaf and Aristidis Tsatsakis and Vardavas, {Alexander I.} and Wenjie Wang and Zeng, {Eddy Y.} and Calabrese, {Edward J.}",

note = "Funding Information: We are grateful to Dr. Patrick H. Brown, Distinguished Professor of Plant Science at the University of California, Davis, U.S.A., and Dr. Adrian Covaci, Professor of Environmental Toxicology and Chemistry at the University of Antwerp, Belgium, for comments and suggestions on an early draft of the paper. This study did not receive a specific grant from funding agencies in the public, commercial, or not-for-profit sectors. E.A. acknowledges support from the National Natural Science Foundation of China (No. 4210070867), The Startup Foundation for Introducing Talent of Nanjing University of Information Science & Technology (NUIST), Nanjing, China (No. 003080), and the Jiangsu Distinguished Professor program of the People{\textquoteright}s Government of Jiangsu Province. E.J.C. acknowledges longtime support from the U.S. Air Force (AFOSR FA9550-13-1-0047) and ExxonMobil Foundation (S18200000000256). The sponsors were not involved in the study design; the collection, analysis or interpretation of the data; the preparation of the manuscript or the decision where to submit the manuscript for publication. All authors hold senior editorial positions in various scientific journals. The views presented herein are those of the authors and do not represent views of journals{\textquoteright} editorial board as a unit, journals{\textquoteright} editorial office, journals themselves or their publishers, authors{\textquoteright} institutions, or scientific societies where authors hold senior positions.",

year = "2022",

month = aug,

day = "16",

doi = "10.1021/acs.est.2c02896",

language = "English (US)",

volume = "56",

pages = "11095--11099",

journal = "Environmental Science and Technology",

issn = "0013-936X",

publisher = "American Chemical Society",

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TY - JOUR

T1 - Rethinking Subthreshold Effects in Regulatory Chemical Risk Assessments

AU - Agathokleous, Evgenios

AU - Barceló, Damià

AU - Aschner, Michael

AU - Azevedo, Ricardo Antunes

AU - Bhattacharya, Prosun

AU - Costantini, David

AU - Cutler, G. Christopher

AU - De Marco, Alessandra

AU - Docea, Anca Oana

AU - Dórea, José G.

AU - Duke, Stephen O.

AU - Efferth, Thomas

AU - Fatta-Kassinos, Despo

AU - Fotopoulos, Vasileios

AU - Ginebreda, Antonio

AU - Guedes, Raul Narciso C.

AU - Hayes, A. Wallace

AU - Iavicoli, Ivo

AU - Kalantzi, Olga Ioanna

AU - Koike, Takayoshi

AU - Kouretas, Demetrios

AU - Kumar, Manish

AU - Manautou, José E.

AU - Moore, Michael N.

AU - Paoletti, Elena

AU - Peñuelas, Josep

AU - Picó, Yolanda

AU - Reiter, Russel J.

AU - Rezaee, Ramin

AU - Rinklebe, Jörg

AU - Rocha-Santos, Teresa

AU - Sicard, Pierre

AU - Sonne, Christian

AU - Teaf, Christopher

AU - Tsatsakis, Aristidis

AU - Vardavas, Alexander I.

AU - Wang, Wenjie

AU - Zeng, Eddy Y.

AU - Calabrese, Edward J.

N1 - Funding Information: We are grateful to Dr. Patrick H. Brown, Distinguished Professor of Plant Science at the University of California, Davis, U.S.A., and Dr. Adrian Covaci, Professor of Environmental Toxicology and Chemistry at the University of Antwerp, Belgium, for comments and suggestions on an early draft of the paper. This study did not receive a specific grant from funding agencies in the public, commercial, or not-for-profit sectors. E.A. acknowledges support from the National Natural Science Foundation of China (No. 4210070867), The Startup Foundation for Introducing Talent of Nanjing University of Information Science & Technology (NUIST), Nanjing, China (No. 003080), and the Jiangsu Distinguished Professor program of the People’s Government of Jiangsu Province. E.J.C. acknowledges longtime support from the U.S. Air Force (AFOSR FA9550-13-1-0047) and ExxonMobil Foundation (S18200000000256). The sponsors were not involved in the study design; the collection, analysis or interpretation of the data; the preparation of the manuscript or the decision where to submit the manuscript for publication. All authors hold senior editorial positions in various scientific journals. The views presented herein are those of the authors and do not represent views of journals’ editorial board as a unit, journals’ editorial office, journals themselves or their publishers, authors’ institutions, or scientific societies where authors hold senior positions.

PY - 2022/8/16

Y1 - 2022/8/16

KW - Chemical Risk Assessments

KW - cancer

KW - hormesis

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U2 - 10.1021/acs.est.2c02896

DO - 10.1021/acs.est.2c02896

M3 - Review article

C2 - 35878124

AN - SCOPUS:85135929481

SN - 0013-936X

VL - 56

SP - 11095

EP - 11099

JO - Environmental Science and Technology

JF - Environmental Science and Technology

IS - 16

ER -

Rethinking Subthreshold Effects in Regulatory Chemical Risk Assessments

Keywords

ASJC Scopus subject areas

UN SDGs

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