Retention of endocrine function by an insulin secreting pancreatic islet cell tumour from Syrian hamster through serial transplantation in nude mice

S. Shin, Stephen G. Baum, N. Fleischer, O. M. Rosen

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

An insulin secreting islet cell tumor of the Syrian hamster was transplanted serially in the congenitally immune deficient nude mouse, in order to test the potential usefulness of this mouse mutant as a graft carrier of heterologous tumors with stable differentiated phenotypes. The incidence of tumor growth was very high, and the hamster tumor retained its functional and histologic characteristics during consecutive passages in these mice. It is concluded that nude mice may be useful carriers of differentiated tumors fron noninbred species including man, and for the isolation of cell lines from such tumors.

Original languageEnglish (US)
Pages (from-to)199-206
Number of pages8
JournalJournal of Cell Science
Volume18
Issue number2
StatePublished - 1975

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Mesocricetus
Nude Mice
Transplantation
Insulin
Neoplasms
Islet Cell Adenoma
Insulin-Secreting Cells
Tumor Cell Line
Cricetinae
Transplants
Phenotype
Pancreatic islet cell tumors
Incidence
Growth

ASJC Scopus subject areas

  • Cell Biology

Cite this

Retention of endocrine function by an insulin secreting pancreatic islet cell tumour from Syrian hamster through serial transplantation in nude mice. / Shin, S.; Baum, Stephen G.; Fleischer, N.; Rosen, O. M.

In: Journal of Cell Science, Vol. 18, No. 2, 1975, p. 199-206.

Research output: Contribution to journalArticle

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