@article{deaabfb7224e464f973cd826ade121f7,
title = "Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria",
abstract = "Abnormal splicing of LMNA gene or aberrant processing of prelamin A results in progeroid syndrome. Here we show that lamin A interacts with and activates SIRT1. SIRT1 exhibits reduced association with nuclear matrix (NM) and decreased deacetylase activity in the presence of progerin or prelamin A, leading to rapid depletion of adult stem cells (ASCs) in Zmpste24-/- mice. Resveratrol enhances the binding between SIRT1 and A-type lamins to increases its deacetylase activity. Resveratrol treatment rescues ASC decline, slows down body weight loss, improves trabecular bone structure and mineral density, and significantly extends the life span in Zmpste24-/- mice. Our data demonstrate lamin A as an activator of SIRT1 and provide a mechanistic explanation for the activation of SIRT1 by resveratrol. The link between conserved SIRT1 longevity pathway and progeria suggests a stem cell-based and SIRT1 pathway-dependent therapeutic strategy for progeria.",
author = "Baohua Liu and Shrestha Ghosh and Xi Yang and Huiling Zheng and Xinguang Liu and Zimei Wang and Guoxiang Jin and Bojian Zheng and Kennedy, {Brian K.} and Yousin Suh and Matt Kaeberlein and Karl Tryggvason and Zhongjun Zhou",
note = "Funding Information: We thank Professor Manfred Wehnert (Institute of Human Genetics, University of Greifswald, Greifswald, Germany) for human dermal fibroblasts harboring various LMNA mutations, Professor Chu-Xia Deng (NIDDK, National Institutes of Health) for SIRT1 null MEFs, Dr. Zhenkun Lou (Mayo Clinic) for FLAG-p53 and p300 constructs, and Professor Qiwei Zhai (Shanghai Institutes for Biological Sciences, CAS, China) for EGFP-SIRT1 construct. This project is supported by a grant from the Progeria Research Foundation; research grants (HKU7655/06M, HKU7655/06M, CRF/HKU3/07C) from RGC of Hong Kong, ITF of Hong Kong (ITS/102/07), and the Ministry of Science and Technology of China (2011CB964700). The authors would like to acknowledge the support from NSFC (30971620), NSFGP (8452402301001450, 9252402301000002), STPP (2008108101045) from Dongguan City, and GDMC (STIF201102). ",
year = "2012",
month = dec,
day = "5",
doi = "10.1016/j.cmet.2012.11.007",
language = "English (US)",
volume = "16",
pages = "738--750",
journal = "Cell metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "6",
}