"resuscitation" of marginal liver allografts for transplantation with machine perfusion technology

Jay A. Graham, James V. Guarrera

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

As the rate of medically suitable donors remains relatively static worldwide, clinicians have looked to novel methods to meet the ever-growing demand of the liver transplant waiting lists worldwide. Accordingly, the transplant community has explored many strategies to offset this deficit. Advances in technology that target the ex vivo "preservation" period may help increase the donor pool by augmenting the utilization and improving the outcomes of marginal livers. Novel ex vivo techniques such as hypothermic, normothermic, and subnormothermic machine perfusion may be useful to "resuscitate" marginal organs by reducing ischemia/reperfusion injury. Moreover, other preservation techniques such as oxygen persufflation are explored as they may also have a role in improving function of "marginal" liver allografts. Currently, marginal livers are frequently discarded or can relegate the patient to early allograft dysfunction and primary non-function. Bench to bedside advances are rapidly emerging and hold promise for expanding liver transplantation access and improving outcomes.

Original languageEnglish (US)
Pages (from-to)418-431
Number of pages14
JournalJournal of Hepatology
Volume61
Issue number2
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Resuscitation
Liver Transplantation
Allografts
Perfusion
Technology
Liver
Tissue Donors
Transplants
Waiting Lists
Reperfusion Injury
Oxygen

Keywords

  • Extended criteria donor
  • Hypothermic
  • Liver
  • Machine preservation
  • Marginal liver
  • Normothermic
  • Organ preservation
  • Perfusion
  • Subnormothermic
  • Transplantation

ASJC Scopus subject areas

  • Hepatology
  • Medicine(all)

Cite this

"resuscitation" of marginal liver allografts for transplantation with machine perfusion technology. / Graham, Jay A.; Guarrera, James V.

In: Journal of Hepatology, Vol. 61, No. 2, 2014, p. 418-431.

Research output: Contribution to journalArticle

@article{27e03d64802840ed9b86d6c22bbbfc86,
title = "{"}resuscitation{"} of marginal liver allografts for transplantation with machine perfusion technology",
abstract = "As the rate of medically suitable donors remains relatively static worldwide, clinicians have looked to novel methods to meet the ever-growing demand of the liver transplant waiting lists worldwide. Accordingly, the transplant community has explored many strategies to offset this deficit. Advances in technology that target the ex vivo {"}preservation{"} period may help increase the donor pool by augmenting the utilization and improving the outcomes of marginal livers. Novel ex vivo techniques such as hypothermic, normothermic, and subnormothermic machine perfusion may be useful to {"}resuscitate{"} marginal organs by reducing ischemia/reperfusion injury. Moreover, other preservation techniques such as oxygen persufflation are explored as they may also have a role in improving function of {"}marginal{"} liver allografts. Currently, marginal livers are frequently discarded or can relegate the patient to early allograft dysfunction and primary non-function. Bench to bedside advances are rapidly emerging and hold promise for expanding liver transplantation access and improving outcomes.",
keywords = "Extended criteria donor, Hypothermic, Liver, Machine preservation, Marginal liver, Normothermic, Organ preservation, Perfusion, Subnormothermic, Transplantation",
author = "Graham, {Jay A.} and Guarrera, {James V.}",
year = "2014",
doi = "10.1016/j.jhep.2014.04.019",
language = "English (US)",
volume = "61",
pages = "418--431",
journal = "Journal of Hepatology",
issn = "0168-8278",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - "resuscitation" of marginal liver allografts for transplantation with machine perfusion technology

AU - Graham, Jay A.

AU - Guarrera, James V.

PY - 2014

Y1 - 2014

N2 - As the rate of medically suitable donors remains relatively static worldwide, clinicians have looked to novel methods to meet the ever-growing demand of the liver transplant waiting lists worldwide. Accordingly, the transplant community has explored many strategies to offset this deficit. Advances in technology that target the ex vivo "preservation" period may help increase the donor pool by augmenting the utilization and improving the outcomes of marginal livers. Novel ex vivo techniques such as hypothermic, normothermic, and subnormothermic machine perfusion may be useful to "resuscitate" marginal organs by reducing ischemia/reperfusion injury. Moreover, other preservation techniques such as oxygen persufflation are explored as they may also have a role in improving function of "marginal" liver allografts. Currently, marginal livers are frequently discarded or can relegate the patient to early allograft dysfunction and primary non-function. Bench to bedside advances are rapidly emerging and hold promise for expanding liver transplantation access and improving outcomes.

AB - As the rate of medically suitable donors remains relatively static worldwide, clinicians have looked to novel methods to meet the ever-growing demand of the liver transplant waiting lists worldwide. Accordingly, the transplant community has explored many strategies to offset this deficit. Advances in technology that target the ex vivo "preservation" period may help increase the donor pool by augmenting the utilization and improving the outcomes of marginal livers. Novel ex vivo techniques such as hypothermic, normothermic, and subnormothermic machine perfusion may be useful to "resuscitate" marginal organs by reducing ischemia/reperfusion injury. Moreover, other preservation techniques such as oxygen persufflation are explored as they may also have a role in improving function of "marginal" liver allografts. Currently, marginal livers are frequently discarded or can relegate the patient to early allograft dysfunction and primary non-function. Bench to bedside advances are rapidly emerging and hold promise for expanding liver transplantation access and improving outcomes.

KW - Extended criteria donor

KW - Hypothermic

KW - Liver

KW - Machine preservation

KW - Marginal liver

KW - Normothermic

KW - Organ preservation

KW - Perfusion

KW - Subnormothermic

KW - Transplantation

UR - http://www.scopus.com/inward/record.url?scp=84904732719&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84904732719&partnerID=8YFLogxK

U2 - 10.1016/j.jhep.2014.04.019

DO - 10.1016/j.jhep.2014.04.019

M3 - Article

C2 - 24768755

AN - SCOPUS:84904732719

VL - 61

SP - 418

EP - 431

JO - Journal of Hepatology

JF - Journal of Hepatology

SN - 0168-8278

IS - 2

ER -