Abstract
Suppressor T-cell function was analyzed in seven children with acquired autoimmunodeficiency syndrome or AIDS-related complex Four of the patients had markedly increased serum IgG levels. All patients had elevated percentages and absolute numbers of peripheral blood T8 cells. In vitro concanavalin A generation of suppressor cells for T-cell mitogenic responses and suppression of pokeweed mitogendriven immunoglobulin secretion were diminished in all patients. After intravenous treatment with gamma globulin, four patients regained in vitro suppression of pokeweed mitogen-driven gamma globulin secretion. Treatment with intravenous gamma globulin also modified in vitro suppressor T-cell functions in children with AIDS or ARC.
Original language | English (US) |
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Pages (from-to) | 143-146 |
Number of pages | 4 |
Journal | American Journal of Diseases of Children |
Volume | 140 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1986 |
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health