Restoration of Suppressor T-Cell Functions in Children With AIDS Following Intravenous Gamma Globulin Treatment

Asha Gupta, Brian E. Novick, Arye Rubinstein

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

Suppressor T-cell function was analyzed in seven children with acquired autoimmunodeficiency syndrome or AIDS-related complex Four of the patients had markedly increased serum IgG levels. All patients had elevated percentages and absolute numbers of peripheral blood T8 cells. In vitro concanavalin A generation of suppressor cells for T-cell mitogenic responses and suppression of pokeweed mitogendriven immunoglobulin secretion were diminished in all patients. After intravenous treatment with gamma globulin, four patients regained in vitro suppression of pokeweed mitogen-driven gamma globulin secretion. Treatment with intravenous gamma globulin also modified in vitro suppressor T-cell functions in children with AIDS or ARC.

Original languageEnglish (US)
Pages (from-to)143-146
Number of pages4
JournalAmerican Journal of Diseases of Children
Volume140
Issue number2
DOIs
StatePublished - Feb 1986

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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