Resting heart rate does not reflect the degree of beta-blockade in subjects with heart failure on chronic beta-blocker therapy

Andrea Mignatti, Daniel B. Sims, Paolo C. Colombo, Luis I. Garcia, Rachel Bijou, Mario C. Deng, Ulrich P. Jorde

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We investigated the relationship between resting heart rate (HR) and two measures of beta-1 receptor sensitivity/blockade: (1) the percentage of maximal predicted heart rate reached during exercise (%MPHR), and (2) the HR increase per unit of circulating norepinephrine (NE) or the chronotropic responsiveness index (CRI) in 28 patients with systolic CHF on chronic beta-blocker therapy. Our results show that resting HR is not associated with HR response during exercise nor with beta-1 receptor sensitivity to circulating NE.

Original languageEnglish (US)
Pages (from-to)42-48
Number of pages7
JournalCardiovascular Therapeutics
Volume27
Issue number1
DOIs
StatePublished - Mar 2009
Externally publishedYes

Fingerprint

Heart Failure
Heart Rate
Norepinephrine
Exercise
Therapeutics

Keywords

  • Beta Blockers
  • Heart Failure
  • Resting Heart Rate (HR)

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)
  • Pharmacology

Cite this

Resting heart rate does not reflect the degree of beta-blockade in subjects with heart failure on chronic beta-blocker therapy. / Mignatti, Andrea; Sims, Daniel B.; Colombo, Paolo C.; Garcia, Luis I.; Bijou, Rachel; Deng, Mario C.; Jorde, Ulrich P.

In: Cardiovascular Therapeutics, Vol. 27, No. 1, 03.2009, p. 42-48.

Research output: Contribution to journalArticle

Mignatti, Andrea ; Sims, Daniel B. ; Colombo, Paolo C. ; Garcia, Luis I. ; Bijou, Rachel ; Deng, Mario C. ; Jorde, Ulrich P. / Resting heart rate does not reflect the degree of beta-blockade in subjects with heart failure on chronic beta-blocker therapy. In: Cardiovascular Therapeutics. 2009 ; Vol. 27, No. 1. pp. 42-48.
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