Resting heart rate does not reflect the degree of beta-blockade in subjects with heart failure on chronic beta-blocker therapy

Andrea Mignatti; Daniel B. Sims; Paolo C. Colombo; Luis I. Garcia; Rachel Bijou; Mario C. Deng; Ulrich P. Jorde

doi:10.1111/j.1755-5922.2009.00072.x

Resting heart rate does not reflect the degree of beta-blockade in subjects with heart failure on chronic beta-blocker therapy

Andrea Mignatti, Daniel B. Sims, Paolo C. Colombo, Luis I. Garcia, Rachel Bijou, Mario C. Deng, Ulrich P. Jorde

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

We investigated the relationship between resting heart rate (HR) and two measures of beta-1 receptor sensitivity/blockade: (1) the percentage of maximal predicted heart rate reached during exercise (%MPHR), and (2) the HR increase per unit of circulating norepinephrine (NE) or the chronotropic responsiveness index (CRI) in 28 patients with systolic CHF on chronic beta-blocker therapy. Our results show that resting HR is not associated with HR response during exercise nor with beta-1 receptor sensitivity to circulating NE.

Original language	English (US)
Pages (from-to)	42-48
Number of pages	7
Journal	Cardiovascular Therapeutics
Volume	27
Issue number	1
DOIs	https://doi.org/10.1111/j.1755-5922.2009.00072.x
State	Published - Mar 1 2009
Externally published	Yes

Keywords

Beta Blockers
Heart Failure
Resting Heart Rate (HR)

ASJC Scopus subject areas

Pharmacology
Cardiology and Cardiovascular Medicine
Pharmacology (medical)

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10.1111/j.1755-5922.2009.00072.x

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AU - Mignatti, Andrea

AU - Sims, Daniel B.

AU - Colombo, Paolo C.

AU - Garcia, Luis I.

AU - Bijou, Rachel

AU - Deng, Mario C.

AU - Jorde, Ulrich P.

PY - 2009/3/1

Y1 - 2009/3/1

N2 - We investigated the relationship between resting heart rate (HR) and two measures of beta-1 receptor sensitivity/blockade: (1) the percentage of maximal predicted heart rate reached during exercise (%MPHR), and (2) the HR increase per unit of circulating norepinephrine (NE) or the chronotropic responsiveness index (CRI) in 28 patients with systolic CHF on chronic beta-blocker therapy. Our results show that resting HR is not associated with HR response during exercise nor with beta-1 receptor sensitivity to circulating NE.

AB - We investigated the relationship between resting heart rate (HR) and two measures of beta-1 receptor sensitivity/blockade: (1) the percentage of maximal predicted heart rate reached during exercise (%MPHR), and (2) the HR increase per unit of circulating norepinephrine (NE) or the chronotropic responsiveness index (CRI) in 28 patients with systolic CHF on chronic beta-blocker therapy. Our results show that resting HR is not associated with HR response during exercise nor with beta-1 receptor sensitivity to circulating NE.

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KW - Heart Failure

KW - Resting Heart Rate (HR)

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Resting heart rate does not reflect the degree of beta-blockade in subjects with heart failure on chronic beta-blocker therapy

Abstract

Keywords

ASJC Scopus subject areas

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