Resting heart rate does not reflect the degree of beta-blockade in subjects with heart failure on chronic beta-blocker therapy

Andrea Mignatti, Daniel B. Sims, Paolo C. Colombo, Luis I. Garcia, Rachel Bijou, Mario C. Deng, Ulrich P. Jorde

Research output: Contribution to journalArticle

6 Scopus citations


We investigated the relationship between resting heart rate (HR) and two measures of beta-1 receptor sensitivity/blockade: (1) the percentage of maximal predicted heart rate reached during exercise (%MPHR), and (2) the HR increase per unit of circulating norepinephrine (NE) or the chronotropic responsiveness index (CRI) in 28 patients with systolic CHF on chronic beta-blocker therapy. Our results show that resting HR is not associated with HR response during exercise nor with beta-1 receptor sensitivity to circulating NE.

Original languageEnglish (US)
Pages (from-to)42-48
Number of pages7
JournalCardiovascular Therapeutics
Issue number1
StatePublished - Mar 1 2009
Externally publishedYes



  • Beta Blockers
  • Heart Failure
  • Resting Heart Rate (HR)

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

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