REST, a master transcriptional regulator in neurodegenerative disease

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

The restrictive element-1 silencing transcription factor)/NRSF (neuron-restrictive silencing factor (NRSF) is a transcriptional repressor which acts via epigenetic remodeling to silence target genes. Emerging evidence indicates that REST is a master transcriptional regulator of neuron-specific genes not only in neurogenesis and neuronal differentiation, but also in differentiated neurons during the critical period in postnatal brain development, where it plays a role in fine-tuning of genes involved in synaptic plasticity, and in normal aging, where it promotes neuroprotection by repressing genes involved in oxidative stress and β-amyloid toxicity. This review focuses on recent findings that dysregulation of REST and REST-dependent epigenetic remodeling provide a central mechanism critical to the progressive neurodegeneration associated with neurologic disorders and diseases including global ischemia, stroke, epilepsy, Alzheimer's and Huntington's disease.

Original languageEnglish (US)
Pages (from-to)193-200
Number of pages8
JournalCurrent Opinion in Neurobiology
Volume48
DOIs
StatePublished - Feb 1 2018

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Neurodegenerative Diseases
Neurons
Nervous System Diseases
Epigenomics
Genes
Transcriptional Silencer Elements
Neuronal Plasticity
Huntington Disease
Neurogenesis
Amyloid
Epilepsy
Alzheimer Disease
Oxidative Stress
Transcription Factors
Ischemia
Stroke
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

REST, a master transcriptional regulator in neurodegenerative disease. / Hwang, Jee Yeon; Zukin, R. Suzanne.

In: Current Opinion in Neurobiology, Vol. 48, 01.02.2018, p. 193-200.

Research output: Contribution to journalReview article

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