Responsive neurostimulation targeting anterior thalamic nucleus in generalized epilepsy

Aline Herlopian, Sydney S. Cash, Emad M. Eskandar, Tara Jennings, Andrew J. Cole

Research output: Contribution to journalArticle

Abstract

Responsive neurostimulation (RNS) has emerged as an adjunctive treatment modality for patients with intractable focal epilepsy who are not surgical candidates or have more than one ictal onset focus. We report a 34-year-old patient with intractable, childhood-onset, genetic generalized epilepsy (GGE) with tonic, atonic, myoclonic and absence seizures treated with RNS. Strip electrodes over the right posterior frontal cortex and depth electrodes placed in the right anterior nucleus were used for event detection and responsive stimulation. Two-year follow-up revealed 90–95% clinical seizure reduction. This case suggests that refractory GGE may be effectively treated with RNS targeting thalamocortical networks.

Original languageEnglish (US)
Pages (from-to)2104-2109
Number of pages6
JournalAnnals of Clinical and Translational Neurology
Volume6
Issue number10
DOIs
StatePublished - Oct 1 2019

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ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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