Response of the Arterial Wall to Endothelial Removal: An Autoradiographic Study

Edward R. Burns, Theodore H. Spaet, Michael B. Stemerman

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The proliferative response of the balloon deendothelialized rabbit aorta was followed by tritiated thymidine labeling. Peak labeling was seen by 6 days after the procedure, with progressively decreasing activity with increasing distance from the lumen. The proliferative response rapidly subsided, so that base-line values were achieved by a month after the vessel insult. The decrease in proliferation occurred even in areas which were not re-endothelialized. The mechanism of this moderating response is presently not explained, but it appears to have adaptive value in preventing excessive lumen occlusion following vascular injury.

Original languageEnglish (US)
Pages (from-to)473-477
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume159
Issue number3
DOIs
StatePublished - Dec 1978

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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