Response of the arterial wall to endothelial removal

An autoradiographic study

Edward R. Burns, T. H. Spaet, M. B. Stemerman

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The proliferative response of the balloon deendothelialized rabbit aorta was followed by tritiated thymidine labeling. Peak labeling was seen by 6 days after the procedure, with progressively decreasing activity with increasing distance from the lumen. The proliferative response rapidly subsided, so that base-line values were achieved by a month after the vessel insult. The decrease in proliferation occurred even in areas which were not re-endothelialized. The mechanism of this moderating response is presently not explained, but it appears to have adaptive value in preventing excessive lumen occlusion following vascular injury.

Original languageEnglish (US)
Pages (from-to)473-477
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume159
Issue number3
StatePublished - 1978

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Vascular System Injuries
Thymidine
Labeling
Aorta
Rabbits
Balloons

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Response of the arterial wall to endothelial removal : An autoradiographic study. / Burns, Edward R.; Spaet, T. H.; Stemerman, M. B.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 159, No. 3, 1978, p. 473-477.

Research output: Contribution to journalArticle

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