Response of routine semen analysis and critical assessment of sperm morphology by kruger classification to therapeutic varicocelectomy

Mónica H. Vazquez-Levin, Patricia Friedmann, Svetlana I. Goldberg, Nadine E. Medley, Harris M. Nagler

Research output: Contribution to journalArticle

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Abstract

Purpose: We studied the effect of varicocelectomy on Kruger morphology and semen parameters. Materials and Methods: A total of 33 subfertile men diagnosed with varicoceles was evaluated 3 months before, and 3 to 4 and 6 to 8 months after varicocelectomy. Evaluation involved routine semen analysis and sperm morphology using Kruger classification. Results: Significant improvement in sperm concentration and count was found after varicocelectomy (sperm count preoperatively 117.1 ± 29, 3 to 4 months postoperatively 162.5 ± 41 and 6 to 8 months postoperatively 139.8 ± 25 million sperm, p = 0.0095). Using Kruger classification, evaluation of sperm morphology revealed overall significant increase in percentage of normal A forms at 3 to 4 and 6 to 8 months after surgery (from 9.8 ± 5.8 % A forms, 13.6 ± 7.7 % A forms, and 14.5 ± 7.5 % A forms, respectively, p = 0.0002, normal greater than 14%). Twelve of the 26 patients (46%) with abnormal sperm morphology preoperatively and greater than 4% A forms reached normal levels S months postoperatively. Six months after surgery only 6 patients maintained normal values and 3 of the initial 14 nonresponders became normal (9 of 26, 36%). Three patients with severe teratozoospermia (less than 4% A forms) showed improvement in sperm morphology. Four patients with normal sperm morphology preoperatively were not affected by varicocelectomy. Conclusions: Surgical correction of varicocele was associated with significant improvement in sperm morphology evaluated using Kruger classification. Concentration and count improved after varicocelectomy. Changes were observed as early as 3 months after surgery.

Original languageEnglish (US)
Pages (from-to)1804-1807
Number of pages4
JournalJournal of Urology
Volume158
Issue number5
DOIs
StatePublished - Nov 1997
Externally publishedYes

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Semen Analysis
Spermatozoa
Varicocele
Sperm Count
Therapeutics
Semen
Reference Values

Keywords

  • Fertilization in vitro
  • Morphogenesis
  • Motility, cell
  • Spermatogenesis
  • Varicocele

ASJC Scopus subject areas

  • Urology

Cite this

Response of routine semen analysis and critical assessment of sperm morphology by kruger classification to therapeutic varicocelectomy. / Vazquez-Levin, Mónica H.; Friedmann, Patricia; Goldberg, Svetlana I.; Medley, Nadine E.; Nagler, Harris M.

In: Journal of Urology, Vol. 158, No. 5, 11.1997, p. 1804-1807.

Research output: Contribution to journalArticle

Vazquez-Levin, Mónica H. ; Friedmann, Patricia ; Goldberg, Svetlana I. ; Medley, Nadine E. ; Nagler, Harris M. / Response of routine semen analysis and critical assessment of sperm morphology by kruger classification to therapeutic varicocelectomy. In: Journal of Urology. 1997 ; Vol. 158, No. 5. pp. 1804-1807.
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abstract = "Purpose: We studied the effect of varicocelectomy on Kruger morphology and semen parameters. Materials and Methods: A total of 33 subfertile men diagnosed with varicoceles was evaluated 3 months before, and 3 to 4 and 6 to 8 months after varicocelectomy. Evaluation involved routine semen analysis and sperm morphology using Kruger classification. Results: Significant improvement in sperm concentration and count was found after varicocelectomy (sperm count preoperatively 117.1 ± 29, 3 to 4 months postoperatively 162.5 ± 41 and 6 to 8 months postoperatively 139.8 ± 25 million sperm, p = 0.0095). Using Kruger classification, evaluation of sperm morphology revealed overall significant increase in percentage of normal A forms at 3 to 4 and 6 to 8 months after surgery (from 9.8 ± 5.8 {\%} A forms, 13.6 ± 7.7 {\%} A forms, and 14.5 ± 7.5 {\%} A forms, respectively, p = 0.0002, normal greater than 14{\%}). Twelve of the 26 patients (46{\%}) with abnormal sperm morphology preoperatively and greater than 4{\%} A forms reached normal levels S months postoperatively. Six months after surgery only 6 patients maintained normal values and 3 of the initial 14 nonresponders became normal (9 of 26, 36{\%}). Three patients with severe teratozoospermia (less than 4{\%} A forms) showed improvement in sperm morphology. Four patients with normal sperm morphology preoperatively were not affected by varicocelectomy. Conclusions: Surgical correction of varicocele was associated with significant improvement in sperm morphology evaluated using Kruger classification. Concentration and count improved after varicocelectomy. Changes were observed as early as 3 months after surgery.",
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AU - Vazquez-Levin, Mónica H.

AU - Friedmann, Patricia

AU - Goldberg, Svetlana I.

AU - Medley, Nadine E.

AU - Nagler, Harris M.

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N2 - Purpose: We studied the effect of varicocelectomy on Kruger morphology and semen parameters. Materials and Methods: A total of 33 subfertile men diagnosed with varicoceles was evaluated 3 months before, and 3 to 4 and 6 to 8 months after varicocelectomy. Evaluation involved routine semen analysis and sperm morphology using Kruger classification. Results: Significant improvement in sperm concentration and count was found after varicocelectomy (sperm count preoperatively 117.1 ± 29, 3 to 4 months postoperatively 162.5 ± 41 and 6 to 8 months postoperatively 139.8 ± 25 million sperm, p = 0.0095). Using Kruger classification, evaluation of sperm morphology revealed overall significant increase in percentage of normal A forms at 3 to 4 and 6 to 8 months after surgery (from 9.8 ± 5.8 % A forms, 13.6 ± 7.7 % A forms, and 14.5 ± 7.5 % A forms, respectively, p = 0.0002, normal greater than 14%). Twelve of the 26 patients (46%) with abnormal sperm morphology preoperatively and greater than 4% A forms reached normal levels S months postoperatively. Six months after surgery only 6 patients maintained normal values and 3 of the initial 14 nonresponders became normal (9 of 26, 36%). Three patients with severe teratozoospermia (less than 4% A forms) showed improvement in sperm morphology. Four patients with normal sperm morphology preoperatively were not affected by varicocelectomy. Conclusions: Surgical correction of varicocele was associated with significant improvement in sperm morphology evaluated using Kruger classification. Concentration and count improved after varicocelectomy. Changes were observed as early as 3 months after surgery.

AB - Purpose: We studied the effect of varicocelectomy on Kruger morphology and semen parameters. Materials and Methods: A total of 33 subfertile men diagnosed with varicoceles was evaluated 3 months before, and 3 to 4 and 6 to 8 months after varicocelectomy. Evaluation involved routine semen analysis and sperm morphology using Kruger classification. Results: Significant improvement in sperm concentration and count was found after varicocelectomy (sperm count preoperatively 117.1 ± 29, 3 to 4 months postoperatively 162.5 ± 41 and 6 to 8 months postoperatively 139.8 ± 25 million sperm, p = 0.0095). Using Kruger classification, evaluation of sperm morphology revealed overall significant increase in percentage of normal A forms at 3 to 4 and 6 to 8 months after surgery (from 9.8 ± 5.8 % A forms, 13.6 ± 7.7 % A forms, and 14.5 ± 7.5 % A forms, respectively, p = 0.0002, normal greater than 14%). Twelve of the 26 patients (46%) with abnormal sperm morphology preoperatively and greater than 4% A forms reached normal levels S months postoperatively. Six months after surgery only 6 patients maintained normal values and 3 of the initial 14 nonresponders became normal (9 of 26, 36%). Three patients with severe teratozoospermia (less than 4% A forms) showed improvement in sperm morphology. Four patients with normal sperm morphology preoperatively were not affected by varicocelectomy. Conclusions: Surgical correction of varicocele was associated with significant improvement in sperm morphology evaluated using Kruger classification. Concentration and count improved after varicocelectomy. Changes were observed as early as 3 months after surgery.

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