TY - JOUR
T1 - Respiratory syncytial virus infection following hematopoietic stem cell transplantation
AU - Small, T. N.
AU - Casson, A.
AU - Malak, S. F.
AU - Boulad, F.
AU - Kiehn, T. E.
AU - Stiles, J.
AU - Ushay, H. M.
N1 - Funding Information:
This work was supported by PO1 CA23766 from the National Cancer Institute, National Institute of Health.
PY - 2002
Y1 - 2002
N2 - Respiratory syncytial virus, one of the most common causes of respiratory infections in immunocompetent individuals, is frequently spread to recipients of HSCT by family members, other patients, and health care workers. In immunosuppressed individuals, progression from upper respiratory tract disease to pneumonia is common, and usually fatal if left untreated. We performed a retrospective analysis of RSV infections in recipients of autologous or allogeneic transplants. The incidence of RSV following allogeneic or autologous HSCT was 5.7% and 1.5%, respectively. Of the 58 patients with an RSV infection, 16 of 21 patients identified within the first post-transplant month, developed pneumonia. Seventy-two percent of patients received aerosolized ribavirin and/or RSV-IGIV, including 23 of 25 patients diagnosed with RSV pneumonia. In this aggressively treated patient population, three patients died of RSV disease, each following an unrelated HSCT.
AB - Respiratory syncytial virus, one of the most common causes of respiratory infections in immunocompetent individuals, is frequently spread to recipients of HSCT by family members, other patients, and health care workers. In immunosuppressed individuals, progression from upper respiratory tract disease to pneumonia is common, and usually fatal if left untreated. We performed a retrospective analysis of RSV infections in recipients of autologous or allogeneic transplants. The incidence of RSV following allogeneic or autologous HSCT was 5.7% and 1.5%, respectively. Of the 58 patients with an RSV infection, 16 of 21 patients identified within the first post-transplant month, developed pneumonia. Seventy-two percent of patients received aerosolized ribavirin and/or RSV-IGIV, including 23 of 25 patients diagnosed with RSV pneumonia. In this aggressively treated patient population, three patients died of RSV disease, each following an unrelated HSCT.
KW - Hematopoietic stem cell transplantation
KW - Respiratory syncytial virus(RSV)
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U2 - 10.1038/sj.bmt.1703365
DO - 10.1038/sj.bmt.1703365
M3 - Article
C2 - 11896429
AN - SCOPUS:85047700513
SN - 0268-3369
VL - 29
SP - 321
EP - 327
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
IS - 4
ER -