Respiratory syncytial virus infection following hematopoietic stem cell transplantation

T. N. Small, A. Casson, S. F. Malak, F. Boulad, T. E. Kiehn, J. Stiles, Henry Michael Ushay

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Respiratory syncytial virus, one of the most common causes of respiratory infections in immunocompetent individuals, is frequently spread to recipients of HSCT by family members, other patients, and health care workers. In immunosuppressed individuals, progression from upper respiratory tract disease to pneumonia is common, and usually fatal if left untreated. We performed a retrospective analysis of RSV infections in recipients of autologous or allogeneic transplants. The incidence of RSV following allogeneic or autologous HSCT was 5.7% and 1.5%, respectively. Of the 58 patients with an RSV infection, 16 of 21 patients identified within the first post-transplant month, developed pneumonia. Seventy-two percent of patients received aerosolized ribavirin and/or RSV-IGIV, including 23 of 25 patients diagnosed with RSV pneumonia. In this aggressively treated patient population, three patients died of RSV disease, each following an unrelated HSCT.

Original languageEnglish (US)
Pages (from-to)321-327
Number of pages7
JournalBone Marrow Transplantation
Volume29
Issue number4
DOIs
StatePublished - Jan 1 2002
Externally publishedYes

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Respiratory Syncytial Virus Infections
Hematopoietic Stem Cell Transplantation
Pneumonia
Transplants
Respiratory Tract Diseases
Respiratory Syncytial Viruses
Ribavirin
Infection
Respiratory Tract Infections
Patient Care
Delivery of Health Care
Incidence
Population

Keywords

  • Hematopoietic stem cell transplantation
  • Respiratory syncytial virus(RSV)

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Respiratory syncytial virus infection following hematopoietic stem cell transplantation. / Small, T. N.; Casson, A.; Malak, S. F.; Boulad, F.; Kiehn, T. E.; Stiles, J.; Ushay, Henry Michael.

In: Bone Marrow Transplantation, Vol. 29, No. 4, 01.01.2002, p. 321-327.

Research output: Contribution to journalArticle

Small, T. N. ; Casson, A. ; Malak, S. F. ; Boulad, F. ; Kiehn, T. E. ; Stiles, J. ; Ushay, Henry Michael. / Respiratory syncytial virus infection following hematopoietic stem cell transplantation. In: Bone Marrow Transplantation. 2002 ; Vol. 29, No. 4. pp. 321-327.
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