Resolution of recurrent hepatitis B in two liver transplant recipients treated with famciclovir

Steven Huy Han, Milan Kinkhabwala, Paul Martin, Curtis Holt, Natalie Murray, Philip Seu, Steven Rudich, D. Hiserodt, David Imagawa, Ronald W. Busuttil

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Recurrent hepatitis B infection after orthotopic liver transplantation remains problematic despite prophylaxis with hepatitis B immune globulin (anti-HBs IgG). Recently, famciclovir (an oral nucleoside analog) has been shown to have potent antiviral activity against hepatitis B in vitro as well as in patients with chronic hepatitis B. We present two patients who developed recurrent hepatitis B after orthotopic liver transplantation and were treated with famciclovir, 500 mg t.i.d. Both patients subsequently responded with marked improvement in biochemical liver tests and histology, with subsequent loss of hepatitis B surface antigen. Famciclovir is a useful agent in the treatment of hepatitis B in the liver transplant recipient.

Original languageEnglish (US)
Pages (from-to)2245-2247
Number of pages3
JournalAmerican Journal of Gastroenterology
Volume93
Issue number11
DOIs
StatePublished - Nov 1998
Externally publishedYes

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Hepatitis B
Liver
Liver Transplantation
Chronic Hepatitis B
Hepatitis B Surface Antigens
Nucleosides
Antiviral Agents
Immunoglobulins
Histology
famciclovir
Transplant Recipients
Infection
Therapeutics

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Resolution of recurrent hepatitis B in two liver transplant recipients treated with famciclovir. / Han, Steven Huy; Kinkhabwala, Milan; Martin, Paul; Holt, Curtis; Murray, Natalie; Seu, Philip; Rudich, Steven; Hiserodt, D.; Imagawa, David; Busuttil, Ronald W.

In: American Journal of Gastroenterology, Vol. 93, No. 11, 11.1998, p. 2245-2247.

Research output: Contribution to journalArticle

Han, SH, Kinkhabwala, M, Martin, P, Holt, C, Murray, N, Seu, P, Rudich, S, Hiserodt, D, Imagawa, D & Busuttil, RW 1998, 'Resolution of recurrent hepatitis B in two liver transplant recipients treated with famciclovir', American Journal of Gastroenterology, vol. 93, no. 11, pp. 2245-2247. https://doi.org/10.1111/j.1572-0241.1998.00626.x
Han, Steven Huy ; Kinkhabwala, Milan ; Martin, Paul ; Holt, Curtis ; Murray, Natalie ; Seu, Philip ; Rudich, Steven ; Hiserodt, D. ; Imagawa, David ; Busuttil, Ronald W. / Resolution of recurrent hepatitis B in two liver transplant recipients treated with famciclovir. In: American Journal of Gastroenterology. 1998 ; Vol. 93, No. 11. pp. 2245-2247.
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