Resection versus expectant management of small incidentally discovered nonfunctional pancreatic neuroendocrine tumors

Alex M. Rosenberg, Patricia Friedmann, Jaydira Del Rivero, Steven K. Libutti, Amanda M. Laird

Research output: Contribution to journalArticle

41 Scopus citations


Background Sporadic, nonfunctional pancreatic neuroendocrine tumors (NF-PNETs) are diagnosed with increasing frequency. We compared the risk of tumor growth, metastasis, and mortality between patients treated versus those treated expectantly. Method A retrospective study of patients seen at our institution with sporadic NF-PNETs, with ≥12 months of follow-up. Kaplan-Meier analysis was performed. Results Between 1999 and 2014, 35 patients with an incidentally discovered nonfunctional PNET were identified. Twenty underwent resection and 15 were followed with imaging. In the operative group, 8 had NF-PNETs <2 cm, while 12 had NF-PNETs ≥ 2 cm. In the nonoperative expectant management by serial imaging group, 10 had NF-PNETs <2 cm while 5 had NF-PNETs ≥ 2 cm. Small NF-PNETs (

Original languageEnglish (US)
Pages (from-to)302-309
Number of pages8
JournalSurgery (United States)
Issue number1
StatePublished - Jan 1 2016


ASJC Scopus subject areas

  • Surgery

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